Memaye (Leea indica (Burm.f.) Merr) has been used by the Besemah tribe in Lahat, South Sumatra to treat several diseases. Memaye leaves contain secondary metabolite compounds such as glycosides, terpenoids, flavonoids and steroids that can be used as infectious and degenerative drugs. This study aims to identify metabolite profiles, dominant compounds, and explore the anti-infective and antideg…