Background : COVID-19 is a disease caused by SARS-CoV-2. Until May 31th 2021, there is still no COVID-19 drug that approved by all parties, and scientist still develop COVID-19 therapy. From COVID-19 causative therapies in Indonesia, there are some protein that targeted from these drugs, like ACE2, 3CLpro, TMPRSS2, and RdRp. In drug discovery, the drug needed to have high affinity and selectivi…