Background Nasopharyngeal carcinoma (NPC) is a malignant tumor that tends to be diagnosed at cm advanced stage, so they have low survival rate and poor prognosis. Cyclooxygenase-2 is an enzyme that is induced during injlammation and neoplastic and expressed in various tumors. The aim of this study is to evaluate the expression of cyclooxygenase-2 in nasopharyngeal carcinoma and to assess the co…