Background: Xanthine oxidase is an enzyme that catalyzes the formation of uric acid. It is known that kersen leaves contains secondary metabolites such as flavonoids, which have antihyperuricemia potential. This study aims to determine the efficacy of the polar fraction of ethyl acetate extract of kersen leaves (Muntingia calabura Linn) as an antihyperuricemia tested in vitro. Methods: Experime…