Skripsi

PENGARUH PEMBERIAN ORALLY DISSOLVING FILM EKSTRAK BUAH MENGKUDU (Morinda citrifolia L.) TERHADAP SEL IMUN TIKUS PUTIH GALUR WISTAR

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Noni fruit (Morinda citrifolia L.) contains flavonoids that have immunomodulatory activity. Orally Dissolving Film (ODF) formulation removes the bitter taste and low bioavailability of extract. This study aims to determine the characteristics of ODF noni fruit extract and the immunomodulatory effects of ODF noni fruit extract in Wistar male rats induced by E. coli on the number of leukocytes, lymphocytes, monocytes, neutrophils, CD4 T cells, macroscopic and histopathological spleen. ODF evaluation included organoleptic, film thickness, film weight, folding endurance, percent elongation, disintegration time, and content uniformity. The rat immunomodulator test divided into normal grup, negative grup, positive grup, group 1 (extract 17.5 mg/KgBW), and group 2 (ODF extract). Treatment for 14 days, induction of E. coli 105 CFU/mL intraperitoneal on day 15 except the normal group. The evaluation results of ODF noni fruit extract had a thickness 0.128±0.001 mm, weight uniformity 0.082±0.001 mg, folding endurance 466.67±0.471, pH 6.10±0.014, percent elongation 33.042±0.010, disintegration time 33.667±0.471 seconds, and content uniformity 100.68±2.760%. ODF significantly decreased the number of leukocytes (34.88%), lymphocytes (34.72%), monocytes (52.48%), neutrophils (71.22%), and CD4 T cells (77.77%) than extract (p

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Detail Information

Series Title

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Call Number

T1141362023

Publisher

Indralaya : Jurusan Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2023

Collation

xviii, 135 hlm.; ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

615.307

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Jurusan Farmasi
Obat-obatan organik

Specific Detail Info

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Statement of Responsibility

PITRIA

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