Skripsi

AKURASI PARAMETER COMPLETE BLOOD COUNT SEBAGAI PREDIKTOR MORTALITAS PASIEN SEPSIS DI UNIT PERAWATAN INTENSIF RS MOHAMMAD HOESIN PALEMBANG

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Background: Sepsis is a leading cause of death in intensive care units (ICU), with high mortality rates. As a routine, inexpensive, rapid, and readily accessible test, the complete blood count (CBC) has the potential to predict mortality. This study aimed to analyze the accuracy of CBC parameters as mortality predictors in ICU patients with sepsis. Methods: A retrospective cohort study was conducted using medical records of sepsis patients treated in the ICU of Mohammad Hoesin Hospital Palembang, from January 1, 2022, to December 31, 2024. Consecutive sampling was applied based on predefined inclusion and exclusion criteria. CBC data (NLR, MLR, PLR, RDW, PDW) were collected on days 1, 2, and 3 of ICU care. ROC curve analysis was performed to determine cut-off points, sensitivity, specificity, and accuracy, followed by bivariate analysis. Multivariable regression was used to identify independent predictors of mortality. Results: A total of 198 patients were analyzed; 77 (38.9%) died during ICU stay. In ROC analysis, day-3 PDW showed the best predictive performance for mortality (AUC 0.716; cut-off >12.55; sensitivity 62.3%; specificity 63.6%; LR+ 1.71; LR– 0.59; accuracy 63.1%). Day-2 MLR (AUC 0.622; cut-off ≤0.74; sensitivity 59.74%, specificity 58.68%; LR+ 1.45; LR– 0.69; accuracy 59.09%), day-2 PLR (AUC 0.614; cut-off ≤254.92; sensitivity 59.74%; specificity 58.67%; LR+ 1.44; LR– 0.68; accuracy 59.09%), day-3 PLR (AUC 0.651; cut-off ≤237.35; sensitivity 59.74%; specificity 58.67%; LR+ 1.44; LR– 0.68; accuracy 59.09%), and day-3 RDW (AUC 0.642; cut-off >14.65; sensitivity 59.74%; specificity 60.33%; LR+ 1.51; LR– 0.67; accuracy 60.10%) provided weak discrimination for predicting ICU mortality. Day-3 NLR emerged as an independent predictor of mortality after adjustment (aOR 3.105; CI95% 1.249-7.717; p = 0.015). Conclusion: In ICU patients with sepsis, Among CBC indices, day-3 PDW demonstrated the best discriminative ability for predicting mortality in ICU sepsis patients. Despite a relatively low AUC, day-3 NLR remained an independent predictor of mortality after covariate adjustment. Keywords: sepsis, mortality, complete blood count

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Detail Information

Series Title

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Call Number

T1854112025

Publisher

Palembang : Program Pendidikan Dokter Spesialis, Fakultas Kedokteran Universitas Sriwijaya., 2025

Collation

viii, 257 hlm.; ilus.; tab.; 29 cm.

Language

Indonesia

ISBN/ISSN

-

Classification

304.640 7

Content Type

Text

Media Type

unmediated

Carrier Type

other (computer)

Edition

-

Subject(s)

Program Pendidikan Dokter Spesialis
Pasien Mortalitas di ICU

Specific Detail Info

-

Statement of Responsibility

MI

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