Skripsi

KORELASI KADAR ANTIBODI ANTI-dsDNA DENGAN DERAJAT AKTIVITAS PENYAKIT PADA PASIEN LUPUS ERITEMATOSUS SISTEMIK DI RSUP DR. MOHAMMAD HOESIN

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Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that involves various body systems and produces various autoantibodies. One of the autoantibodies in SLE is anti-double stranded deoxyribonucleic acid (anti-dsDNA) which is found in 70% of patients with SLE. Anti-dsDNA antibody has high specificity so it has been used as an indicator of disease activity. This study aims to determine the correlation of anti-dsDNA antibody levels with the degree of disease activity in SLE patients at RSUP Dr. Mohammad Hoesin. This study used an analytic observational study design with a cross sectional approach. Samples in this study were taken from medical records and laboratory examination results of SLE patients at RSUP Dr. Mohammad Hoesin. Samples that met the inclusion criteria were analyzed using the Spearman statistical test to identify the correlation between anti-dsDNA antibodies and the degree of disease activity using the Mexican Systemic Lupus Erythematosus Disease Activity Index (MEX-SLEDAI). The total number of samples in this study was 33. Most patients were female (87.9%), most were in the age range of 18-44 years (87.9%), most had negative anti-dsDNA antibody levels (51.5%), and most had mild disease activity (54.5%). Bivariate analysis showed no significant correlation between anti-dsDNA antibody levels and MEX-SLEDAI score in this sample (p = 0.893). This study did not find a significant correlation between anti-dsDNA antibody levels and the degree of disease activity in SLE patients at RSUP Dr. Mohammad Hoesin. Keywords: SLE, Systemic Lupus Erythematosus, Anti-dsDNA, Disease Activity, MEX-SLEDAI

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Detail Information

Series Title

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Call Number

T1603612024

Publisher

Indralaya : Prodi Pendidikan Kedokteran, Fakultas Kedokteran Universitas Sriwijaya., 2024

Collation

xv, 30 hlm.; ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

616.525 07

Content Type

Text

Media Type

unmediated

Carrier Type

-

Edition

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Subject(s)

Lupus eritematosus sistemik
Prodi Pendidikan Kedokteran

Specific Detail Info

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Statement of Responsibility

TUTI

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