Image of HUBUNGAN KELEBIHAN ZAT BESI DENGAN FUNGSI HATI PADA PASIEN ANAK THALASSEMIA BERGANTUNG TRANSFUSI DI RSUP DR. MOHAMMAD HOESIN PALEMBANG
Bookmark Share

Skripsi

HUBUNGAN KELEBIHAN ZAT BESI DENGAN FUNGSI HATI PADA PASIEN ANAK THALASSEMIA BERGANTUNG TRANSFUSI DI RSUP DR. MOHAMMAD HOESIN PALEMBANG

Pediatric transfusion-dependent thalassemia patients require lifelong transfusion to compensate for inadequate erythrocyte and to support patient’s growth and development. However, regular transfusion can cause iron overload leading to oxidative stress-induced liver injury. The purpose of this study is to analyze the relationship between iron overload and liver function in pediatric transfusion-dependent thalassemia patients at RSUP Dr. Mohammad Hoesin Palembang. This study is an analytical observational study with a cross-sectional study design. This study included 139 pediatric transfusion-dependent thalassemia patients at RSUP Dr. Mohammad Hoesin Palembang aged between 1-18 years old. This study used secondary data consisting of sociodemographic characteristics, iron status, and liver function obtained from patient’s medical record. The Chi-Square and Fisher test is used to analyze the relationship between each indicator of iron status and liver function in the patients. Majority of patients have ≥ 1000 µg/L serum ferritin (88,5%), ≥ 70% transferrin saturation (68,3%), and high total bilirubin (69,8%). Most patients have normal SGOT (59,0%), SGPT (59,7%), PT (97,8%), APTT (87,8%), and albumin (97,1%). All patients have normal total protein. Iron overload has significant relationships with SGOT (p=0,003 and p=0,001) and SGOT (p=0,003 and p=0,001), but not with PT (p=0,309 and p=0,235), APTT (p=0,693 and 0,442), total bilirubin (p=0,776 dan p=0,607), and albumin (p=0,390 and p=1,000). Iron overload has significant relationships with SGOT and SGPT in pediatric transfusion-dependent thalassemia patients at RSUP Dr. Mohammad Hoesin Palembang. Kata Kunci: Thalassemia Bergantung Transfusi, Kelebihan Zat Besi, Fungsi Hati.

Availability
#
Central Library (REFERENCE) T1603112024
T160311
Available but not for loan - Not for Loan
Detail Information
Series Title
-
Call Number
T1603112024
Publisher
Indralaya : Prodi Pendidikan Kedokteran, Fakultas Kedokteran Universitas Sriwijaya.,
Collation
xv, 42 hlm.; ilus.; 29 cm
Language
Indonesia
ISBN/ISSN
-
Classification
618.928 07
Content Type
Text
Media Type
unmediated
Carrier Type
-
Edition
-
Subject(s)
Prodi Pendidikan Kedokteran
Anak – Penyakit Darah.
Specific Detail Info
-
Statement of Responsibility
Other version/related

No other version available

File Attachment
Comments
You must be logged in to post a comment