Skripsi
HUBUNGAN ANTARA BAYI BERAT LAHIR RENDAH DAN KEJADIAN SEPSIS NEONATORUM
Low birth weight (LBW) is one of the main causes of increased neonatal morbidity and mortality. Infants with a birth weight of less than 2,500 grams have an immature immune system, making them more susceptible to systemic infections such as neonatal sepsis. This study aimed to determine the relationship between LBW and the incidence of neonatal sepsis at Mohammad Hoesin Hospital Palembang in 2024. The study employed an analytical observational with a retrospective cohort design. Secondary data were obtained from neonatal medical records and registers from January 1 to December 31, 2024. The sample consisted of 778 neonates who met the inclusion criteria, selected using the total sampling technique. Data were analyzed using the Chi-Square test and the Cochrane-Armitage Trend Test. The characteristics of neonatal sepsis cases showed that most infants had normal birth weight (55.6%), were male (58.9%), had term gestational age (57.8%), were delivered by cesarean section (55.6%), had a length of stay ≥7 days (88.9%), and were mostly referral cases (71.1%). The incidence of neonatal sepsis among all neonates was 11.4%, the incidence of low birth weight (LBW) was 25.3%, and the incidence of sepsis among LBW infants was 15.9%. The analysis showed a significant relationship between LBW and neonatal sepsis (p=0.013) and RR=1,67 (95% CI 1.13 – 2.46) indicating that LBW infants had a 1.67 times higher risk of developing sepsis compared to infants with normal birth weight The analysis of the relationship between the degree of birth weight and sepsis also showed significant results (p=0.019) and RR=1,462 (95% CI 1.065 – 2.007).This study confirms that LBW is an important risk factor for neonatal sepsis; therefore, close monitoring, infection prevention, and early intervention are required to reduce the risk of sepsis and its complications. Keywords: Low birth weight, Neonatal sepsis, Risk factor