Skripsi

KORELASI HbA1c DENGAN INDEKS ATEROGENIK PLASMA, KOEFISIEN ATEROGENIK, DAN INDEKS RISIKO CASTELLI PADA PASIEN DIABETES MELITUS TIPE 2

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Background: Hyperglycemia in type 2 DM, characterized by elevated HbA1c, can cause diabetic dyslipidemia, which increases cardiovascular risk. Various atherogenic indices are used to predict this risk. This study aims to analyze the correlation of HbA1c with atherogenic index of plasma (AIP), atherogenic coefficient (AC), and Castelli risk index (CRI) in type 2 DM patients. Methods: This observational analytical study with a cross-sectional design involved 167 type 2 DM outpatients at Mohammad Hoesin Hospital in Palembang from January to December 2024, selected using consecutive sampling. Data analysis was performed using univariate and bivariate analysis with independent t-test/Mann-Whitney U tests, Pearson and Spearman correlation tests, and one-way ANOVA test. Results: The majority of subjects were female (58.7%) with a median age of 61 years, fasting blood glucose 115 mg/dL, random blood glucose 151 mg/dL, HbA1c 7.9%, total cholesterol 192 mg/dL, triglycerides 143 mg/dL, HDL-C 45 mg/dL, and mean LDL-C 130.90 mg/dL. A total of 38.3% of subjects were of normal weight, 49.7% had prehypertension, 100% used antihyperglycemic drugs, and 56.3% used moderate-intensity statins. The mean AIP, AC, CRI-I, and CRI-II were 0.49, 3.26, 4.26, and 2.87, respectively. Only the difference in AIP was significant based on glycemic control. The correlation between HbA1c and AIP, AC, CRI-I, and CRI-II was not significant. Differences in AIP, AC, CRI-I, and CRI-II based on statin intensity were not significant. In addition, the correlation of HbA1c with IAP, KA, IRC-I, and IRC-II based on statin intensity was not significant. Conclusion: There was no significant correlation between HbA1c and AIP, AC, CRI-I, and CRI-II in type 2 DM patients.

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Detail Information

Series Title

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Call Number

T1870172025

Publisher

Palembang : Prodi Pendidikan Kedokteran, Fakultas Kedokteran Universitas Sriwijaya., 2025

Collation

xx, 169 hlm.; ilus.; tab.; 29 cm.

Language

Indonesia

ISBN/ISSN

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Classification

616.462 07

Content Type

Text

Media Type

unmediated

Carrier Type

other (computer)

Edition

-

Subject(s)

Diabetes Melitus Tipe 2
Prodi Pendidikan Kedokteran

Specific Detail Info

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Statement of Responsibility

MI

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