Skripsi

PERBEDAAN HASIL LABORATORIUM BAYI DENGAN KOLESTASIS BERDASARKAN USIA DATANG DI RSUP DR. MOHAMMAD HOESIN PALEMBANG

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Background: Cholestasis is a condition characterized by impaired bile formation and/or obstruction of bile flow, commonly occurring within the first three months of life. The age at presentation influences the clinical outcomes of infants with cholestasis. Infants presenting after three months of age have surpassed the ideal period for early detection and evaluation of cholestasis as recommended. This study aimed to analyze the differences in laboratory results of infants with cholestasis based on age at presentation at Dr. Mohammad Hoesin General Hospital, Palembang. Methods: This was an analytical observational study with a cross-sectional design. Samples were obtained using a total sampling technique. Secondary data were collected from medical records of inpatients and outpatients diagnosed with cholestasis at Dr. Mohammad Hoesin General Hospital, Palembang, from January 1, 2023, to December 31, 2024. The collected data were subsequently analyzed. Results: This study included 106 infants with cholestasis, consisting of 59 (55.7%) with intrahepatic cholestasis and 47 (44.3%) with extrahepatic cholestasis. Most patients were ≤3 months old (57.5%), male (56.6%), born at term (68.9%), and had a birth weight of 2,500–3,999 grams (73.6%). Intrahepatic cholestasis was more common among males and those ≤3 months old (67.8%), while extrahepatic cholestasis was more common among females and those >3 months old (55.3%). There were significant associations between age at presentation, sex, gestational age, and birth weight with the type of cholestasis (p0.05). Conclusion: No significant differences were observed in total bilirubin, ALT, AST, ALP, or GGT levels between age groups within intrahepatic cholestasis and extrahepatic cholestasis. Keywords: Cholestasis, Laboratory Findings, Age at Presentation

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Detail Information

Series Title

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Call Number

T1870022025

Publisher

Palembang : Prodi Pendidikan Kedokteran, Fakultas Kedokteran Universitas Sriwijaya., 2025

Collation

xvii, 90 hlm.; ilus.; tab.; 29 cm.

Language

Indonesia

ISBN/ISSN

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Classification

616.362 307

Content Type

Text

Media Type

unmediated

Carrier Type

other (computer)

Edition

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Subject(s)

Prodi Pendidikan Kedokteran
Kolestasis

Specific Detail Info

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Statement of Responsibility

MI

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