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ANALISIS ENZIM AST DAN ALT PADA PEMBERIAN EKSTRAK DAUN UBI JALAR UNGU (IPOMOEA BATATAS L.) PADA TIKUS YANG DIINDUKSI CCL4

Background: The liver is susceptible to damage due to exposure to free radicals, which trigger oxidative stress. This condition increases AST and ALT enzymes, which are markers of liver injury. This study used CClâ‚„-induced Wistar rats as a model of liver damage. Antioxidants are needed to prevent damage, and silymarin was used as a positive control. Purple sweet potato leaf extract contains flavonoids with antioxidant activity. This study aimed to determine the potential of purple sweet potato leaf extract in reducing AST and ALT in rats with liver damage. Methods: This was an in vivo analytical experimental study with a post-test control group design. The study was conducted from July to November 2024. The study took place in the Animal House, Biochemistry Laboratory, and Biotechnology Laboratory, Faculty of Medicine, Sriwijaya University. Results: CCl4 induction significantly increased AST and ALT levels in the negative control group compared to the normal control group. A high dose (750 mg/kgBW) provided a better effect compared to other doses, indicating a dose-dependent effect of the extract. Phytochemical tests revealed the presence of antioxidant compounds that support liver protection. Conclusion: Administering purple sweet potato leaf extract at a higher dose improved AST and ALT enzyme levels in CCl4-induced rats, indicating potential hepatoprotection.

Availability
#
Central Library (Reference) T1871122025
T187112
Available but not for loan - Not for Loan
Detail Information
Series Title
-
Call Number
T1871122025
Publisher
Palembang : Prodi Pendidikan Kedokteran, Fakultas Kedokteran Universitas Sriwijaya.,
Collation
xix, 112 hlm.; ilus.; tab.; 29 cm.
Language
Indonesia
ISBN/ISSN
-
Classification
616.075 607
Content Type
Text
Media Type
unmediated
Carrier Type
other (computer)
Edition
-
Subject(s)
Prodi Pendidikan Kedokteran
Analisis Laboratorium/Enzim
Specific Detail Info
-
Statement of Responsibility
Other version/related
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