Skripsi

KORELASI JUMLAH TROMBOSIT DAN INDEKS TROMBOSIT DENGAN TROPONIN T PADA PASIEN SINDROM KORONER AKUT

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Acute coronary syndrome (ACS) is one of the leading causes of cardiovascular morbidity and mortality worldwide, including in Indonesia. This condition occurs due to the sudden obstruction of coronary blood flow caused by rupture or erosion of atherosclerotic plaques. Platelet activation plays a role in the process of atherothrombosis and the formation of coronary thrombi. Platelet indices such as Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), and Platelet Large Cell Ratio (P-LCR) reflect platelet activity, size, and heterogeneity, which are associated with the severity of ischemic heart disease. Troponin T is a specific biomarker for myocardial cell injury and is used in the diagnosis of acute coronary syndrome. This study is an analytical observational study with a cross-sectional design, using secondary data from medical records of ACS patients at Mohammad Hoesin Hospital Palembang in 2024. The sample was obtained using consecutive sampling, yielding 79 patients who met the inclusion and exclusion criteria. Data analysis was performed using the Spearman test because most of the data were not normally distributed. A total of 79 patients were analyzed, consisting of 48 (60,8%) males and 31 (39,2%) females. The largest age group was 55–64 years (40,5%). Distribution of risk factors included hypertension (50,6%), dyslipidemia (84,8%), diabetes mellitus (41,8%), and obesity (10,1%). Distribution of the main variables: platelet count 264/mm³ (150/mm³ – 575/mm³), MPV 10.1 fL (8,6 fL – 12,4 fL), PDW 11 fL (7,6 fL – 18,6 fL), P-LCR (26,638% ± 7,2411%), and Troponin T 141 ng/L (10 ng/L – 7123 ng/L). Spearman’s test showed the following correlation for platelet count (r = 0,078; p = 0,497), MPV (r = 0,039; p = 0,733), PDW (r = −0,069; p = 0,543), and P-LCR (r = −0,004; p = 0,972) with Troponin T (p > 0,05). This study concludes that there is no significant correlation between platelet count and platelet indices with Troponin T in ACS patients.

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Detail Information

Series Title

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Call Number

T1870182025

Publisher

Palembang : Prodi Pendidikan Kedokteran, Fakultas Kedokteran Universitas Sriwijaya., 2025

Collation

xviii, 88 hlm.; ilus.; tab.; 29 cm.

Language

Indonesia

ISBN/ISSN

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Classification

616.120 7

Content Type

Text

Media Type

unmediated

Carrier Type

other (computer)

Edition

-

Subject(s)

Prodi Pendidikan Kedokteran
Sindrom Koroner Akut

Specific Detail Info

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Statement of Responsibility

MI

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