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PEMBUATAN PEMBALUT LUKA HIDROGEL BERBASIS PVA/CMC DENGAN PENAMBAHAN MINYAK LADA HITAM SEBAGAI ANTIBAKTERI

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This study aims to develop a hydrogel wound dressing based on Polyvinyl Alcohol (PVA) and Carboxymethyl Cellulose (CMC) with the addition of black pepper oil (Piper nigrum L.) as a natural antibacterial agent. The hydrogel was made with varying concentrations of CMC (5%, 7.5%, 10%) and black pepper oil (0–40%) using citric acid as a crosslinking agent and gum arabic as a binder. Analysis was carried out on antibacterial activity, water absorption (swelling degree), water solubility, mechanical properties (tensile strength and elongation at break), and clinical trials on animals. The results showed that increasing the concentration of black pepper oil increased the inhibitory power against Staphylococcus aureus up to a clear zone diameter of 8.83 mm, indicating moderate antibacterial activity. The highest swelling degree value reached 446%, according to wound dressing standards (200–500%), while water solubility tended to decrease with increasing black pepper oil due to its hydrophobic properties. The mechanical properties meet the tensile strength standards for wound dressings (5–15 N/mm²). Clinical trials showed 9% wound healing on day 7. Overall, the combination of PVA/CMC 3:2 with 20% black pepper oil produced a hydrogel with the best physical, antibacterial, and biocompatibility properties, making it potentially suitable for use as an environmentally friendly antibacterial wound dressing. Keywords: Antibacterial, CMC, Black Pepper Extract, Hydrogel, PVA, Wound Dressing.

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Detail Information

Series Title

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Call Number

T1871352025

Publisher

Palembang : Prodi Magister Teknik Kimia, Fakultas Teknik Universitas Sriwijaya., 2025

Collation

xiii, 63 hlm.; ilus.; tab, 29 cm.

Language

Indonesia

ISBN/ISSN

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Classification

668.907

Content Type

Text

Media Type

unmediated

Carrier Type

other (computer)

Edition

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Subject(s)

Prodi Magister Teknik Kimia
Teknologi Polymer

Specific Detail Info

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Statement of Responsibility

SEW

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