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PENGARUH PENGGUNAAN ANTIBIOTIK TERHADAP PENINGKATAN POLA RESISTENSI BAKTERI NEONATAL INTENSIVE CARE UNIT (NICU) RS DR. MOHAMMAD HOESIN PALEMBANG PERIODE 2022-2024

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Antibiotic resistance in the NICU continues to be a global problem, increasing neonatal mortality and morbidity rates. Excessive broad-spectrum empiric antibiotic therapy increases the DOT (Days of Therapy) per 1000 patient-days metric and promotes resistance development through selective pressure. The high antibiotic usage in the NICU prompted research on the effect of DOT per 1000 patient-days antibiotic utilization on increasing bacterial resistance patterns in the NICU of Dr. Mohammad Hoesin Hospital Palembang during the 2022-2024 period. This study employed an analytical cross-sectional method using secondary data from the Hospital Information System Installation, Central Laboratory, and Clinical Microbiology Laboratory of Dr. Mohammad Hoesin Hospital Palembang during 2022-2024. Using total sampling technique, 262 patients were analyzed for DOT per 1000 patient-days metric calculation and 157 patients were analyzed for blood culture findings. Data analysis included identification of the 10 most common antibiotics and 10 most common bacterial isolates, as well as evaluation of resistance patterns every six months. Based on the research conducted on NICU patients during 2022-2024, the most prevalent isolates were CoNS (51%), Klebsiella pneumoniae (17%), and Acinetobacter baumannii (16%). Resistance dynamics demonstrated a correlation between DOT per 1000 patient-days metric and increased resistance, particularly with ampicillin use against Escherichia coli isolates. Endemic resistance (CRE, CRAB) requires more aggressive intervention, while reserve agents (tigecycline, vancomycin) are preserved with minimal DOT per 1000 patient-days strategy. Therefore, an increase in DOT per 1000 patient- days of first-line antibiotic use directly causes an increase in resistance patterns through selective pressure. Integrated interventions (DOT reduction and infection control) are capable of reversing endemic resistance. Reserve agents were successfully preserved with an ultra-minimal DOT per 1000 patient-days strategy.

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Detail Information

Series Title

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Call Number

T1871962025

Publisher

Indralaya : Prodi Pendidikan Dokter, Fakultas Kedokteran Universitas Sriwijaya., 2025

Collation

xxiii, 237 hlm.; ilus.; tab, 29 cm.

Language

Indonesia

ISBN/ISSN

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Classification

615.329 07

Content Type

Text

Media Type

unmediated

Carrier Type

other (computer)

Edition

-

Subject(s)

Antibiotik
Prodi Pendidikan Dokter

Specific Detail Info

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Statement of Responsibility

SEW

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