Skripsi

ANALISIS JARINGAN PROTEIN DAN SENYAWA HERBAL UNTUK MENENTUKAN TARGET TERAPI PADA INFARK MIOKARD YANG BERHUBUNGAN DENGAN MITOKONDRIA

---

Introduction: Myocardial infarction (MI) is a leading cause of global mortality with reperfusion therapy as its the gold standard. However, the following myocardial ischemia-reperfusion injury (MIRI) still lacks effective pharmacologic treatment. Mapping protein interaction networks may help identify herbal-based therapeutic targets related to mitochondria which holds central role in energy metabolism, oxidative stress regulation, and cell death. Methods: This exploratory study data-mined MI-related and mitochondrial proteins from several databases. Herbal compounds were identified from primary research articles retrieved through several electronic databases. Overlapping protein sets were analyzed using STITCH and STRING, then visualized in Cytoscape. Key proteins were defined based on cluster formation and top-ten rankings in four network centrality parameters. Results: The intersection of the three datasets revealed proteins that consistently appeared across all groups and were involved in cell-cycle regulation, apoptosis, autophagy and cell death, intracellular signaling, regulation of oxidative reactions, lipid metabolism, ubiquinone biosynthesis, and calcium homeostasis. TP53, AKT1, CYCS, CREB1, MAPK8, HSPA4, BECN1, MTOR, and GSK3B consistently ranked within the top 10 across all centrality parameters. Conclusion: This study identifies several key proteins implicated in MI pathogenesis that are mitochondrial-related and concurrently targeted by herbal compounds, exhibiting strong functional roles and connectivity within the protein interaction network. Keywords: Herbal, myocardial infarction, protein network, mitochondria

---

Availability

Detail Information

Series Title

-

Call Number

T1877412025

Publisher

Palembang : Prodi Pendidikan Dokter, Fakultas Kedokteran Universitas Sriwijaya., 2025

Collation

xvii, 145 hlm.; ilus.; tab, 29 cm

Language

Indonesia

ISBN/ISSN

-

Classification

615.107

Content Type

Text

Media Type

-

Carrier Type

-

Edition

-

Subject(s)

Prodi Pendidikan Dokter
Farmakologi--Target Terapi Obat

Specific Detail Info

-

Statement of Responsibility

MI

Other version/related

File Attachment

Comments

---

You must be logged in to post a comment