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UJI AKTIVITAS EKSTRAK DAUN KARAMUNTING (RHODOMYRTUS TOMENTOSA (AITON) HASSK) TERHADAP BAKTERI SERRATIA MARCESCENS

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Background: Nosocomial infections remain a major problem with high incidence rates globally and in Indonesia, contributing to morbidity and mortality, especially with the increasing antibiotic resistance including Serratia marcescens, a multidrug-resistant organism and a common Gram-negative pathogen in ICUs. Indonesia is rich in herbal plants, one of which is karamunting leaf (Rhodomyrtus tomentosa (Aiton) Hassk) containing flavonoids, tannins, saponins, phenols, and triterpenoids, and has been shown to inhibit Gram-negative bacteria. However, no studies have examined its effect on Serratia marcescens, so antibacterial testing is necessary. Objective: To determine the antibacterial activity of karamunting leaf extract against Serratia marcescens by assessing the Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC), and the secondary metabolite compounds present in the extract. Method: This descriptive experimental study was conducted in vitro using 10 treatment groups through broth dilution and disk diffusion methods at concentrations of 10000 µg/mL, 8000 µg/mL, 6000 µg/mL, 4000 µg/mL, 2000 µg/mL, 1000 µg/mL, 500 µg/mL, 250 µg/mL, 125 µg/mL, and a control solution, with four replicates each. Results: The study showed inhibitory activity of karamunting leaf extract against Serratia marcescens at a concentration of 8000 µg/mL. Conclusion: The ethanol extract of karamunting leaf showing a weak antibacterial activity against Serratia marcescens.

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Detail Information

Series Title

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Call Number

T1876472025

Publisher

Palembang : Prodi Pendidikan Dokter, Fakultas Kedokteran Universitas Sriwijaya., 2025

Collation

xvii, 83 hlm.; ilus.; tab, 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

615.320 7

Content Type

Text

Media Type

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Carrier Type

-

Edition

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Subject(s)

Prodi Pendidikan Dokter
Ekstrak Daun Karamunting

Specific Detail Info

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Statement of Responsibility

MI

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