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MEKANISME DISBIOSIS MIKROBIOTA USUS PADA SINDROM OVARIUM POLIKISTIK MELALUI PEMERIKSAAN JUMLAH MIKROBA, ZONULIN, SHORT CHAIN FATTY ACIDS, INSULIN-LIKE GROWTH FACTOR-1,HOMEOSTASIS MODEL ASSESSMENT OF INSULIN RESISTANCE DAN JUMLAH FOLIKEL OVARIUM

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Mechanism of Gut Microbiota Dysbiosis in Polycystic Ovary Syndrome Through the Assessment of Microbial Count, Zonulin, Short Chain Fatty Acids, Insulin-like Growth Factor-1, Homeostasis Model Assessment of Insulin Resistance, and Ovarian Follicle Count Background: Polycystic ovary syndrome (PCOS) with insulin resistance is a complex endocrine disorder involving multifactorial interactions between metabolic, hormonal, and gut microbial systems. Gut microbiota dysbiosis may play a role in the pathophysiology of PCOS through the gut-brain-gonad axis. This study aimed to analyze the relationship between gut microbiota dysbiosis, intestinal permeability (Zonulin), microbial metabolites (Short Chain Fatty Acids/SCFAs), IGF-1 regulation, insulin resistance (HOMA-IR), and folliculogenesis in a rat model of PCOS with insulin resistance. Methods: This experimental study involved female Wistar rats divided into a control group and a PCOS-insulin resistance model group. Gut microbiota analysis was conducted along with measurements of Zonulin, SCFAs, IGF-1, HOMA-IR levels, and ovarian follicle count. Structural pathway analysis was used to evaluate the contribution of each parameter within the gut-brain-gonad axis framework. Results: A significant decrease in Lactobacillus sp. count and SCFA levels was observed, along with increased levels of Zonulin, IGF-1, and HOMA-IR in the PCOS model group. The number of immature follicles was significantly elevated. Pathway analysis revealed a significant sequential relationship: PCOS → Lactobacillus sp. → SCFAs → IGF-1 → follicle count, supporting the involvement of gut microbiota dysbiosis in the pathophysiology of PCOS. Conclusion: Gut microbiota dysbiosis plays a crucial role in metabolic disturbances and impaired folliculogenesis in a PCOS model with insulin resistance. The gut-brain-gonad axis provides a novel conceptual framework for understanding PCOS pathophysiology and offers a foundation for developing microbiota-targeted non-hormonal therapeutic strategies. Keywords: Polycystic ovary syndrome, gut microbiota dysbiosis, SCFAs, Zonulin, IGF-1, HOMA-IR, gut-brain-gonad axis

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Detail Information

Series Title

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Call Number

T1840542025

Publisher

Palembang : Prodi Sains Biomedis Program Doktor Fakultas Kedokteran Universitas Sriwijaya., 2025

Collation

xxi, 158 hlm.; ilus.; tab.; 29 cm.

Language

Indonesia

ISBN/ISSN

-

Classification

618.140 7

Content Type

Text

Media Type

unmediated

Carrier Type

other (computer)

Edition

-

Subject(s)

Penyakit Pada Rahim
Prodi Sains Biomedis

Specific Detail Info

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Statement of Responsibility

SEW

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