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OPTIMASI GREEN SYNTHESIS NANOPARTIKEL Ag-Fe3O4 MENGGUNAKAN EKSTRAK AIR BUNGA TELANG (Clitoria ternatea L.) DAN COATING AGENT PEG-6000 UNTUK TERAPI TROMBOLITIK SECARA PHOTOTHERMAL

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Thrombosis caused by blood clot formation can lead to serious complications. Conventional therapies carry a risk of bleeding, making photothermal therapy based on optical-magnetic nanoparticles such as AgNO₃ and Fe₃O₄ a safer alternative. These nanoparticles are synthesized via green synthesis using butterfly pea flower (Clitoria ternatea L.) extract, which contains flavonoids and anthocyanins as natural reducing, stabilizing, and thrombolytic agents. This study aims to analyze the effects of varying concentrations of the coating agent and butterfly pea extract on temperature, photothermal efficiency, and thrombolytic activity, as well as to assess the nanoparticle stability in PBS and blood, and to characterize the optimal formulation of silver–magnetite nanoparticles. The experimental design used in this study is a 2² factorial design, consisting of 2 factors each at 2 levels. The factors are the concentration of the coating agent (PEG 6000) and the concentration of the extract (butterfly pea aqueous extract). The levels used are the minimum and maximum concentrations. The concentration variations tested were PEG 6000 (10% and 20%) and butterfly pea extract (5% and 20%). The optimal formulation obtained was PEG 6000 at a concentration of 16.17% and butterfly pea extract at 20%. This formulation produced spherical nanoparticles with a particle size of 457 nm. Fourier transform infrared spectroscopy (FTIR) analysis identified functional groups O-H, C-H, aromatic C=O/C=C, and C-O from the bioactive compounds in butterfly pea and PEG, along with Fe–O bands and indications of Ag–O interactions. Based on the results, the synthesized nanoparticles demonstrated a temperature increase which, when combined with PBS, improved thermal stability but reduced heating efficiency, while in the absence of PBS, the temperature was higher but less stable. The formulation exhibited significant thrombolytic activity when exposed to 450 and 550 nm lasers, although this was accompanied by increased hemolytic activity. Overall, the synthesized nanoparticles show potential as thrombolytic agents.

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Detail Information

Series Title

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Call Number

T1841272025

Publisher

Indralaya : Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2025

Collation

xx, 175 hlm.; ilus.; tab.; 29 cm.

Language

Indonesia

ISBN/ISSN

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Classification

615.807

Content Type

Text

Media Type

unmediated

Carrier Type

other (computer)

Edition

-

Subject(s)

Prodi Ilmu Farmasi
Terapi Fisik dan Jenis Jenis Terapi

Specific Detail Info

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Statement of Responsibility

SEW

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