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GAMBARAN DERAJAT AKTIVITAS PENYAKIT LUPUS ERITEMATOSUS SISTEMIK SEBELUM DAN SESUDAH TERAPI IMUNOSUPRESAN DI RUMAH SAKIT MOHAMMAD HOESIN

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Background. Systemic Lupus Erythematosus (SLE) is a chronic multisystem autoimmune disease characterized by the production of autoantibodies and excessive immune activation, resulting in widespread organ damage. Immunosuppressive therapy constitutes a cornerstone in the management of SLE by suppressing abnormal immune responses and preventing further organ injury. The effectiveness of such therapy may vary among individuals, depending on disease activity levels. Evaluating changes in disease activity before and after immunosuppressive therapy is essential to assess treatment response, particularly in referral centers such as Dr. Mohammad Hoesin Hospital, Palembang. Methods. This study employed an analytical observational design with a pretestposttest approach. The study population consisted of SLE patients receiving immunosuppressive therapy at Dr. Mohammad Hoesin Hospital who met the inclusion criteria. Disease activity was assessed using the Mexican Systemic Lupus Erythematosus Disease Activity Index (MEX-SLEDAI) before and after six months of immunosuppressive treatment. Data were analyzed using univariate and bivariate methods with the Wilcoxon test, and a p-value < 0.05 was considered statistically significant. Results. Most patients were female and within the productive age range. Immunosuppressive therapy was shown to reduce systemic lupus erythematosus (SLE) disease activity, with 76.9% of patients experiencing improvement in their MEX-SLEDAI scores after six months of treatment. The three-drug combination (methylprednisolone, mycophenolate mofetil, and hydroxychloroquine) produced the most significant reductions in both the MEX-SLEDAI scores and the overall disease activity level. Conclusion. There was a significant difference in disease activity scores before and after immunosuppressive therapy among SLE patients at Dr. Mohammad Hoesin Hospital. Immunosuppressive therapy was proven effective in reducing disease activity in SLE. Keywords. Systemic Lupus Erythematosus, Immunosuppressive Therapy, MEX-SLEDAI, Disease Activity

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Series Title

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Call Number

T1873742025

Publisher

Palembang : Prodi Pendidikan Dokter, Fakultas Kedokteran Universitas Sriwijaya., 2025

Collation

xvi, 59 hlm.; ilus.; tab, 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

616.770 7

Content Type

Text

Media Type

unmediated

Carrier Type

other (computer)

Edition

-

Subject(s)

Prodi Pendidikan Dokter
Penyakit pada Jaringan Ikat

Specific Detail Info

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Statement of Responsibility

SEW

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