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EFEKTIVITAS EKSTRAK CUNG KEDIRO TERHADAP KETEBALAN LAPISAN EPITEL, PEMBENTUKAN LAPISAN KERATIN, DAN JUMLAH PEMBULUH DARAH PADA JARINGAN KULIT TIKUS WISTAR

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Background: Wound healing is a complex biological process that progresses through the phases of inflammation, proliferation, and remodeling. Cung kediro (Solanum lycopersicum var. cerasiforme) contains lycopene, β–carotene, vitamin C, and flavonoids, which act as potent antioxidants and have the potential to accelerate epithelialization, angiogenesis, and keratinization. This study aimed to evaluate the effectiveness of cung kediro extract on epithelial thickness, blood vessel count, and keratin layer formation in the skin tissue of Wistar rats. Methods: This experimental study was conducted in vitro using histopathological preparations of Wistar rat skin on day 9. Samples were divided into five groups: negative control, positive control (NaCl 0.9%), and treatment groups receiving cung kediro extract at concentrations of 8%, 12%, and 16%. Observed parameters included epithelial thickness, blood vessel count, and keratin layer formation. Statistical analysis consisted of the Shapiro–Wilk normality test, followed by the Kruskal–Wallis test and Dunn post-hoc analysis, with a significance level of α = 0.05. Results: Cung kediro extract significantly increased epithelial thickness, blood vessel count, and keratin layer formation compared with the negative control group (p < 0.05). The 16% concentration demonstrated the highest effect and showed no significant difference compared with the positive control group (p > 0.05), indicating comparable effectiveness to the standard treatment. Conclusion: Cung kediro extract effectively enhances epithelial thickness, blood vessel formation, and keratin layer development in the skin tissue of Wistar rats. The 16% concentration is the most optimal dose, and its effectiveness increases proportionally with rising extract concentrations (dose-dependent). Keywords: cung kediro, epithelialization, angiogenesis, keratinization, wound healing.

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Series Title

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Call Number

T1876072025

Publisher

Palembang : Prodi Pendidikan Dokter, Fakultas Kedokteran Universitas Sriwijaya., 2025

Collation

xvi, 80 hlm.; ilus.; tab, 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

615.307

Content Type

Text

Media Type

unmediated

Carrier Type

other (computer)

Edition

-

Subject(s)

Prodi Pendidikan Dokter
Obat Obatan Organik

Specific Detail Info

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Statement of Responsibility

SEW

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