Text

ANALISIS PERUBAHAN INTERVAL QT PADA PASIEN TBC RESISTAN OBAT YANG MENDAPATKAN REGIMEN BERBASIS BEDAQUILINE DI RSUP DR. MOHAMMAD HOESIN 2022–2025

---

Background: Management of drug-resistant tuberculosis (DR-TB) has improved with the introduction of shorter regimens following the approval of bedaquiline in 2012. Despite its benefits, bedaquiline carries a black box warning due to its potential to prolong the QT interval, raising concerns about cardiotoxicity. This study aimed to evaluate changes in QTcF, determine the prevalence of QT prolongation, and identify risk factors among DR-TB patients receiving bedaquiline-based regimens at Dr. Mohammad Hoesin Hospital. Methods: This analytic study used a retrospective longitudinal design based on secondary data from medical records and electrocardiograms. Eligible participants were DR-TB patients treated with bedaquiline between 2022 and 2025 who met inclusion criteria. Serial QTcF measurements were analyzed using repeated measures ANOVA, while logistic and linear regression were applied to assess associations with QT prolongation and peak QTcF values. Results: There was a significant increase in QTcF from baseline to the sixth month of therapy (RM-ANOVA p < 0.001). Among 123 patients, grade 1 QT prolongation was most frequently observed (17.1–22.8%), whereas severe prolongation remained rare. Logistic regression showed no significant association between demographic characteristics and QTcF prolongation. Linear regression indicated that older age and lower body mass index were independently associated with higher peak QTcF values, although these variables accounted for only a small proportion of variance (p < 0.05; R² = 0.095). Conclusion: QTcF increased significantly during treatment with bedaquiline-based regimens, emphasizing the need for continuous ECG monitoring to detect and reduce the risk of cardiotoxicity. Keywords: Bedaquiline, drug-resistant tuberculosis, QT Interval, cardiotoxicity.

---

Availability

Detail Information

Series Title

-

Call Number

T1876732025

Publisher

Palembang : Prodi Pendidikan Dokter, Fakultas Kedokteran Universitas Sriwijaya., 2025

Collation

xxiv, 95 hlm.; ilus.; tab, 29 cm

Language

Indonesia

ISBN/ISSN

-

Classification

616.240 7

Content Type

Text

Media Type

unmediated

Carrier Type

other (computer)

Edition

-

Subject(s)

Prodi Pendidikan Dokter
Penyakit pada Paru Paru

Specific Detail Info

-

Statement of Responsibility

SEW

Other version/related

File Attachment

Comments

---

You must be logged in to post a comment