Skripsi

LUARAN PASIEN ANAK LEUKEMIA MIELOBLASTIK AKUT DI RUMAH SAKIT DR MOHAMMAD HOESIN PALEMBANG DAN FAKTOR-FAKTOR YANG MEMENGARUHINYA

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Background: Leukemia is a hematopoietic malignancy characterized by abnormal leukocyte production in the bone marrow. The mortality and incidence rates of children with leukemia are the highest among all childhood cancers. One type of leukemia is acute myeloid leukemia (AML). About 20% of AML cases occur in children. The outcomes of children with AML may be influenced by several factors. Objective: To identify the factors influencing the outcomes of children with acute myeloid leukemia at Dr. Mohammad Hoesin Hospital Palembang. Methods: This study is an observational analytic study with a retrospective cohort design involving 55 pediatric patients diagnosed with AML between 2018 until 2023. Data were obtained from the registry and medical records of Dr. Mohammad Hoesin Hospital Palembang. Results: In this study, 61,8% of patients died, 29,1% relapse, and 30,9% achieved complete remission during the observation period. Bivariate analysis showed that nutritional status was associated with mortality in children with AML (p = 0,016). In addition, initial leukocyte count at diagnosis was associated with relapse (p = 0,047). There no factors were found to be associated with remission (p > 0,05). Multivariate analysis showed that nutritional status was an independent factor influencing mortality, whereas leukocyte count was an independent factor influencing relapse in children with AML. Conclusion: Nutritional status was associated with mortality in children with AML, while initial leukocyte count was associated with relapse. In this study, nutritional status was known as an independent factor of mortality and initial leukocyte count was an independent factor of relapse. Keywords: acute myeloid leukemia, children, outcomes, mortality, relapse, remission.

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Detail Information

Series Title

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Call Number

T1896062025

Publisher

Palembang : Prodi Pendidikan Dokter, Fakultas Kedokteran Universitas Sriwijaya., 2025

Collation

xvii, 117 hlm.; ilus.; tab.; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

616.994 07

Content Type

Text

Media Type

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Carrier Type

-

Edition

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Subject(s)

Prodi Pendidikan Dokter
Leukemia Mieloblastik Akut

Specific Detail Info

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Statement of Responsibility

MI

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