Skripsi

UJI AKTIVITAS PENYEMBUHAN LUKA TERBUKA FRAKSI ETIL ASETAT DAUN SINGKONG (Manihot esculenta) PADA TIKUS PUTIH JANTAN GALUR SPRAGUE DAWLEY

---

National injury prevalence tends to increase every year. Wounds must be healed immediately because they are an important role in maintaining homeostasis and have the potential to become chronic infections if not treated. Cassava leaves (Manihot esculenta) contain the main substance rutin or quercetin 3-O-rutinoside (flavonoids) and contain saponins and tannins as anti-inflammatory, antibacterial and antioxidant which can help the wound healing process. This research is aiming to find the effect of giving ethyl acetate from cassava leaf fraction towards open wound healing rate. The test animal that consist of 25 Sprague Dawley rats, divided into 5 groups which consist of negative control test, positive control test, control test K1, K2, and K3. The observed parameter include wound diameter, wound healing time, and healing percentage. Diameter of wound was analyzed using ANOVA test to observe the differences between certain days of the observation. The research result shows that ethyl acetate fraction from cassava leaf (Manihot esculenta) with 20% dossage is proven to accelerate the healing rate in rats that achieved healing rate of 100% in 14 days, where there was no significant difference (p>0,05) between cassava leaf fraction at a dose of 20% against the positive control (Tekasol®) and significantly different from the negative control. Also, there is significant difference (p

---

Availability

Detail Information

Series Title

-

Call Number

T1526592024

Publisher

Indralaya : Prodi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2024

Collation

xiii, 35 hlm.; ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

-

Classification

615.323 670 7

Content Type

Text

Media Type

unmediated

Carrier Type

-

Edition

-

Subject(s)

Tikus putih jantan
Prodi Farmasi

Specific Detail Info

-

Statement of Responsibility

KA

Other version/related

File Attachment

Comments

---

You must be logged in to post a comment