Skripsi

UJI AKTIVITAS DIURETIK FRAKSI ETIL ASETAT DAUN GAMAL (Gliricidia sepium) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR

---

Hypertension provides a major risk factor for cardiovascular and kidney disease. One of a therapy that used to treat a hypertension is diuretics. Gamal (Gliricidia sepium)contains flavonoid compounds which have diuretic effect. This study aims to determined activity of ethyl acetate fraction of gamal leaves as diuretic by measuring urine volume output and Na⁺, Cl⁻, dan K⁺ ion contents. The animal test was divided into 6 groups, normal group (distilled water), negative group (Na CMC 0.5%), positive group (furosemide), and the treatment groups 1, 2, and 3 were given ethyl acetate fraction of gamal leaves at dose 62.5mg/KgBW, 125mg/KgBW, and 250mg/KgBW. Data were analyzed by one way ANOVA. The result of the analysis of assay showed that urine volume output and Na⁺, Cl⁻, dan K⁺ ion levels at dose 250mg/KgBW were not significantly different from the positive control group (p>0.05). The effective dose of ethyl acetate fraction of gamal leaves is 91.63mg/KgBW. Increasing the dose provides an increase of urine volume and ion contents in the urine.

---

Availability

Detail Information

Series Title

-

Call Number

T1526872024

Publisher

Indralaya : Prodi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2024

Collation

xvi, 107 hlm.; ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

-

Classification

615.321 07

Content Type

Text

Media Type

unmediated

Carrier Type

-

Edition

-

Subject(s)

Prodi Farmasi
Farmakologi eksperimental

Specific Detail Info

-

Statement of Responsibility

KA

Other version/related

File Attachment

Comments

---

You must be logged in to post a comment