Skripsi

HUBUNGAN DENSITAS REGULATORY T-CELL DENGAN PROGNOSIS DIFFUSE LARGE B-CELL LYMPHOMA

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Background: Diffuse large B-cell lymphoma (DLBCL) is the most common subtype, with 150,000 new cases yearly. Roughly 40% of patients who receive rituximab in addition to vincristine, cyclophosphamide, doxorubicin, and prednisone treatment have primary refractory disease or recurrence. Although the Ann Arbor stage could determine DLBCL prognosis, new biomarkers are needed to stratify patient prognosis adequately. Regulatory T-cell (Treg) subsets in the microtumor environment characterized by CD25+ FOXP3+ phenotype are known to play a role in immune modulation, further affecting DLBCL progression and prognosis. However, the Treg role is still controversial. This study aims to determine the Treg density and its correlation with the clinicopathologic features and DLBCL prognosis. Methods: An observational analytic study with a retrospective cohort study was conducted using 44 DLBCL samples period January 1st, 2019 to December 31st, 2022. All samples were immunostained with anti-CD25/anti-FOXP3 double-stained. Clinicohistopathology and overall survival data were obtained through medical records and telephone contact. Bivariate data and multivariate Cox's regression analysis were performed with the Hierarchically Well Formulated (HWF) principle, interaction assessment, and confounding assessment. Results: Bivariate analysis showed high Treg density was associated with early stage (I and II) DLBCL (p=0.001). The prognosis predictors that were independently associated with survival were LDH level [p

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Availability

Detail Information

Series Title

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Call Number

T1518072024

Publisher

Indralaya : Program Pendidikan Dokter Spesialis 1, Patologi Anatomi Fakultas Kedokteran Universitas Sriwijaya., 2024

Collation

ix, 86 hlm.; ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

616.994 460 7

Content Type

Text

Media Type

unmediated

Carrier Type

-

Edition

-

Subject(s)

Patologi Anatomi
Prodi Program Pendidikan Dokter Spesialis 1

Specific Detail Info

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Statement of Responsibility

KA

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