Text

EFEKTIVITAS PENAMBAHAN DIACEREIN TERHADAP KADAR TNF-α DAN KENDALI GLIKEMIK PADA PASIEN DIABETES MELITUS TIPE 2 TIDAK TERKONTROL DI RSUP MOHAMMAD HOESIN PALEMBANG

---

Background: Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia resulting from impaired insulin secretion or insulin resistance, with chronic low-grade inflammation playing a role in its pathogenesis. Diacerein has anti-inflammatory effects and improves insulin sensitivity; however, clinical evidence in Indonesia remains limited. Objective: To evaluate the effect of adding diacerein on serum TNF-α levels and glycemic control in patients with uncontrolled T2DM. Methods: This double-blind randomized controlled trial was conducted on uncontrolled T2DM patients at Mohammad Hoesin General Hospital, Palembang, who received standard therapy plus either diacerein 50 mg twice daily or placebo for 90 days. Measured parameters included TNF-α, glycated hemoglobin (HbA1c), and fasting blood glucose (FBG) before and after intervention. Bivariate and multivariate analyses were used to assess the intervention effect and baseline factors influencing changes. Results: Diacerein administration significantly reduced TNF-α levels from 2.84 ± 0.69 to 2.00 ± 0.59 ng/mL (p = 0.007), HbA1c from 9.96% to 8.88% (p = 0.002), and FPG from 215.9 to 149.46 mg/dL (p = 0.004). Multivariate analysis showed that changes in TNF-α were influenced by baseline body mass index (BMI) and baseline HbA1c. Changes in FPG were influenced by baseline FPG, while changes in HbA1c were influenced by age, BMI, and type of antidiabetic therapy. No serious adverse events were observed; mild diarrhea occurred in one patient and resolved spontaneously. Conclusion: Twelve weeks of diacerein administration significantly reduced TNF-α levels compared with baseline. Diacerein also significantly improved glycemic control, as evidenced by greater reductions in HbA1c and FPG compared with the control group. Therapeutic response was influenced by baseline clinical factors, particularly BMI, age, baseline glycemic levels, and type of antidiabetic therapy.

---

Availability

Detail Information

Series Title

-

Call Number

T1934412026

Publisher

Palembang : Progam Pendidikan Dokter Spesialis-1, Fakultas Kedokteran Universitas Sriwijaya., 2026

Collation

xix, 79 hlm.; ilus.; tab.; 29 cm

Language

Indonesia

ISBN/ISSN

-

Classification

616.462 07

Content Type

Text

Media Type

unmediated

Carrier Type

other (computer)

Edition

-

Subject(s)

Penyakit diabetes mellitus
Progam Pendidikan Dokter Spesialis-1

Specific Detail Info

-

Statement of Responsibility

SEW

Other version/related

File Attachment

Comments

---

You must be logged in to post a comment