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HUBUNGAN GLOBAL LONGITUDINAL STRAIN VENTRIKEL KIRI DENGAN MAJOR ADVERSE CARDIOVASCULAR EVENTS DAN KESINTASAN ENAM BULAN PADA PASIEN HEMODIALISIS KRONIK DI RSUP DOKTER MOHAMMAD HOESIN PALEMBANG

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Introduction: Cardiovascular disease is the leading cause of morbidity and mortality in chronic haemodialysis patients. Conventional assessment of systolic function using left ventricular ejection fraction (LVEF) is often less sensitive in detecting subclinical myocardial dysfunction that impacts short-term prognosis. Left ventricular Global Longitudinal Strain (GLS) is suspected to be closely related to the risk of Major Adverse Cardiovascular Events (MACE) and patient survival. This study aims to analyse the association between left ventricular GLS and the incidence of MACE and six-month survival in chronic haemodialysis patients at Dr. Mohammad Hoesin General Hospital, Palembang. Methods: This was an observational analytic study with a prospective cohort design. Subjects were patients undergoing routine haemodialysis with preserved LVEF (>50%) who met the inclusion and exclusion criteria. Speckle-tracking echocardiography was performed to measure GLS values. The relationship between GLS and clinical outcomes (MACE and mortality) was analysed using Kaplan-Meier curves and Cox Proportional Hazard regression. Results: A total of 123 patients were included in this study with a mean age of 54.5 years and a median haemodialysis duration of 36 months. The incidence of MACE over six months was 43.9%, and the mortality rate reached 23.6%. Multivariate analysis showed that abnormal left ventricular GLS (>-16%) was a strong independent predictor of MACE (aHR 4.38; 95% CI: 1.15–16.68; p=0.031) and six-month mortality (aHR 3.08; 95% CI: 1.12–8.45; p=0.029). Diabetes mellitus was also identified as a significant independent risk factor, whereas conventional LVEF was not proven to be an independent predictor. Conclusion: Abnormal left ventricular Global Longitudinal Strain (GLS) is significantly associated with an increased risk of MACE and decreased six-month survival in chronic haemodialysis patients. GLS has superior prognostic value compared to conventional LVEF in this population. Keywords: Global longitudinal strain, chronic haemodialysis, major adverse cardiovascular events (MACE), survival, LVEF

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Series Title

-

Call Number

T1933762026

Publisher

Palembang : Progam Pendidikan Dokter Spesialis-1, Fakultas Kedokteran Universitas Sriwijaya., 2026

Collation

xvi, 94 hlm.; ilus.; tab.; 29 cm

Language

Indonesia

ISBN/ISSN

-

Classification

615.399 07

Content Type

Text

Media Type

unmediated

Carrier Type

other (computer)

Edition

-

Subject(s)

Progam Pendidikan Dokter Spesialis-1
Cuci Darah

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Statement of Responsibility

SEW

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