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EFIKASI PEMBERIAN LARUTAN DEKSTROSA 25% ORAL UNTUK MENGATASI NYERI PADA TINDAKAN PENGAMBILAN SAMPEL DARAH VENA NEONATUS

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Procedural pain is a common clinical issue in neonates, particularly during venipuncture. Inadequately managed pain can trigger physiological stress, hemodynamic instability, and may negatively affect long-term neurodevelopment. Non-pharmacological analgesic strategies such as oral dextrose have become a practical option due to their simplicity, safety, and ability to reduce reliance on pharmacological agents. To evaluate the efficacy of oral 25% dextrose solution in reducing pain scores based on the Neonatal Infant Pain Scale (NIPS) and to assess its effects on physiological parameters in neonates undergoing venous blood sampling. This randomized controlled trial included 100 neonates, randomized to receive either 25% dextrose (n=50) or sterile distilled water as a placebo (n=50). Pain scores and physiological indicators were measured at four time points: 2 minutes before intervention, and at 1, 5, and 10 minutes post-intervention. Statistical analysis was performed using the Independent T-test and Repeated Measures ANOVA. The dextrose group demonstrated significantly lower NIPS scores than placebo at all post-intervention time points (p < 0.001 for all). No significant differences in physiological parameters were observed between groups (p > 0.05). Oral 25% dextrose effectively reduces procedural pain, likely by activating endogenous analgesic pathways, without clinically meaningful alterations in physiological stability. The analgesic effect appears rapidly and persists for up to ten minutes post-procedure, supporting its safety and clinical utility as a standard non-pharmacological pain management strategy in neonatal care. Oral 25% dextrose solution is effective and safe in reducing procedural pain in neonates. Keywords: Oral 25% dextrose, venipuncture, neonatal pain, NIPS, non-pharmacological analgesia

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Detail Information

Series Title

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Call Number

T1899122025

Publisher

Indralaya : Prodi Pendidikan Dokter Spesialis, Fakultas Kedokteran Universitas Sriwijaya., 2025

Collation

xv, 74 hlm.; ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

618.920 107

Content Type

Text

Media Type

unmediated

Carrier Type

-

Edition

-

Subject(s)

Prodi Pendidikan Dokter Spesialis
MENGATASI NYERI

Specific Detail Info

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Statement of Responsibility

KA

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