Skripsi

UJI DIAGNOSTIK ALAT PEMERIKSAAN CEPAT LATERAL FLOW IMMUNOCHROMATOGRAPHIC ASSAY TERHADAP BIAKAN PADA PASIEN KANDIDIASIS VULVOVAGINALIS

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Background: Vulvovaginal candidiasis (VVC) is a very common mucosal infection in the vagina and vulva, mostly caused by Candida albicans. Accurate diagnosis requires supportive examinations such as direct microscopic evaluation or fungal culture; however, in practice, these ancillary tests are often omitted in women presenting with vulvovaginal symptoms due to high patient burden and the need for specialized microscopic expertise. Culture examination is also limited because it is expensive and takes a long time, and its availability is still limited in some health services. In the community, currently many women are diagnosing and then self-treating vulvovaginal candidiasis which can lead to over or under treatment which can lead to an increased risk of recurrent VVC and contribute to antifungal resistance. Several point-of-care tests (POCTs) have been developed to assist with VVC diagnosis, including the lateral flow immunochromatographic assay (LFIA), which is simple, economical, and capable of providing rapid results. Objective: To determine whether the POCT-LFIA Antigen Combo Test Kit has the same excellent diagnostic performance as fungal culture for the diagnosis of vulvovaginal candidiasis. Methods: Descriptive study with a diagnostic test study design Results: Forty-two of 54 study subjects (77.8%) were confirmed to have VVC based on direct KOH microscopy and fungal culture. Of the 42 culture-positive samples, 41 tested positive on the POCT- LFIA, while one culture-positive sample yielded a negative POCT-LFIA result. Diagnostic test analysis showed a sensitivity of 97.62% (95% CI: 87.43–99.94%), specificity of 100% (95% CI: 73.54–100%), positive predictive value of 100% (95% CI: 91.4–100%), negative predictive value of 92.31% (95% CI: 63.38–98.81%), and diagnostic accuracy of 98.15% (95% CI: 90.11–99.95%). Conclusion: The LFIA point-of-care test demonstrates excellent diagnostic performance that are similar or nearly equivalent to those of fungal culture for the detection of vulvovaginal candidiasis. Keywords: vulvovaginal candidiasis , lateral flow immunochromatographic assay, point of care test

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Detail Information

Series Title

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Call Number

T1913782025

Publisher

Indralaya : Prodi Pendidikan Dokter Spesialis, Fakultas Kedokteran Universitas Sriwijaya., 2025

Collation

xxvi, 67 hlm.; ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

616.075 607

Content Type

Text

Media Type

unmediated

Carrier Type

-

Edition

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Subject(s)

Prodi Pendidikan Dokter Spesialis
Kandidiasis Vulvovaginalis

Specific Detail Info

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Statement of Responsibility

KA

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