Skripsi

HUBUNGAN DERAJAT KEPARAHAN DENGAN SENSITISASI ALERGEN PADA RINITIS ALERGIKA ANAK

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Allergic rhinitis is a chronic inflammation of the nasal mucosa mediated by immunoglobulin E and is one of the most common allergic diseases in children, with a global prevalence of approximately 10–30%. Allergen sensitization plays an important role in determining disease severity, and polysensitization is often associated with more severe clinical manifestations, although data in Indonesian pediatric populations remain limited. This study was an analytical observational research with a cross-sectional design involving 52 children aged 2–18 years diagnosed with allergic rhinitis at Dr. Mohammad Hoesin General Hospital, Palembang, from November 2024 to May 2025. Specific immunoglobulin E levels were measured using an Indonesian allergen panel immunoassay, while disease severity was classified according to the Allergic Rhinitis and Its Impact on Asthma (ARIA) criteria. Statistical analysis was conducted using the Chi-Square test with a significance level of p < 0,05. Results showed that most subjects fell into the mild intermittent category, accounting for 31 children or 60%, and sensitization to house dust mites was found to be the most prevalent. Polysensitization was observed in 24 children (57%) and demonstrated a significant association with allergic rhinitis severity (p < 0.001; OR = 37.8; 95% CI: 4.3–326.0). These findings indicate that exposure to multiple allergens may enhance nasal mucosal inflammation through increased immunoglobulin E production and effector cell activation, leading to more severe symptoms and reduced therapeutic response. Therefore, early detection of sensitization patterns and comprehensive allergen mapping are essential to support more personalized, targeted, and effective management of allergic rhinitis in children.

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Detail Information

Series Title

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Call Number

T1899972025

Publisher

Indralaya : Prodi Magister Ilmu Kesehatan Anak, Fakultas Kedokteran Universitas Sriwijaya., 2025

Collation

ix, 74 hlm.; ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

618.922 120 7

Content Type

Text

Media Type

unmediated

Carrier Type

-

Edition

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Subject(s)

Derajat Keparahan
Prodi Magister Ilmu Kesehatan Anak

Specific Detail Info

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Statement of Responsibility

KA

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