Skripsi

UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL KULIT BATANG TANAMAN SUKUN (Artocarpus altilis) PADA TIKUS WISTAR DENGAN TUKAK LAMBUNG

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Excessive free radicals can induce oxidative stress, which contributes to the development of gastric ulcers. Antioxidants play a crucial role in neutralizing free radicals, thereby preventing cellular damage. The bark of breadfruit (Artocarpus altilis) contains secondary metabolites such as flavonoids and phenolic compounds that exhibit antioxidant potential. This study aimed to evaluate the characteristics of the ethanolic extract of breadfruit bark and its antioxidant activity by measuring malondialdehyde (MDA) levels and assessing catalase and superoxide dismutase (SOD) enzyme activities in rats induced with absolute ethanol. The experimental design consisted of six groups: a normal control group, a positive control group receiving omeprazole (20 mg/kgBB), a negative control group administered 0.5% Na-CMC, and three treatment groups given ethanol extract doses of 100, 200, and 400 mg/kgBB. The results of the characterization of the ethanolic extract of breadfruit stem bark meet the general requirements for herbal extracts based on the Indonesian Herbal Pharmacopoeia. The mean MDA levels in the normal, positive control, negative control, and treatment groups (100, 200, and 400 mg/kgBB) were 0.243, 0.195, 0.531, 0.475, 0.388, and 0.202 nmol/mL, respectively. The mean catalase activities were 15.449, 17.795, 8.433, 10.792, 13.749, and 17.113 U/mL, respectively, while the mean SOD activities were 1.395, 1.560, 0.954, 1.052, 1.258, and 1.516 U/mL, respectively. The ethanol extract at a dose of 400 mg/kg body weight exhibited the highest antioxidant activity, with statistical analysis (p > 0.05) indicating no significant difference compared to the control group.

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Detail Information

Series Title

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Call Number

T1921152026

Publisher

Indralaya : Prodi Pendidikan Fisika, Fakultas Keguruan dan Ilmu Pendidikan Universitas Sriwijaya., 2026

Collation

xii, 147 hlm.; ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

615.321 07

Content Type

Text

Media Type

unmediated

Carrier Type

-

Edition

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Subject(s)

Prodi Pendidikan Fisika
Artocarpus altilis

Specific Detail Info

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Statement of Responsibility

KA

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