Skripsi

PREDIKTOR WAKTU PENEKANAN VIRAL LOAD PADA ORANG DENGAN HIV DI PROVINSI SUMATERA SELATAN TAHUN 2022-2024

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Background : Viral load testing is a key predictor of HIV disease progression and a main indicator of antiretroviral therapy (ART) success, with a target of ≤1,000 copyes/mL. South Sumatra Province faces challenges in achieving the Ending AIDS 2030 targets due to low viral load testing coverage in 2024, which remains below the national target. This study aimed to estimate the time to viral load suppression and identify its predictors among people living with HIV (PLHIV) in a setting with a concentrated epidemic and low HIV prevalence. Methods : This retrospective cohort study used secondary data from the SIHA 2.1 (Sistem Informasi HIV/ AIDS versi 2.1) involving 1,002 PLHIV. Variables analyzed included sociodemographic characteristics, clinical stage, treatment adherence, ART regimen, treatment delivery method, treatment interruption history, Tuberculosis (TB) co-infection, family support, and peer group support. Data were analyzed descriptively and using Cox proportional hazards regression with Stata version 15. Results : Multivariable analysis showed employment status (p = 0,047; HR = 1,45; 95% CI: 0,68–1,44), clinical stage (p < 0.001; HR = 1,55; 95% CI: 1,26–1,91), treatment adherence (p = 0,028; HR = 1,18; 95% CI: 1,02–1,37), TB co-infection (p = 0,001; HR = 1,35; 95% CI: 1,13–1,62), ART regimen type (p = 0,007; HR = 1,37; 95% CI: 1,09–1,71), and family support (p < 0,001; HR = 1,43; 95% CI: 1,19–1,71) were significantly associated with time to VL suppression after adjusting for sex, education, age, MMD, Lost to follow up history and peer support. Conclusion : Adherence, TB co-infection, Type of ART regimen, employment status, Family support, and clinical stage were significant predictors of time to viral load suppression. Clinical stage and TB co-infection can influence treatment adherence and viral load suppression. Improving viral load suppression rates retention is essential to accelerate VL suppression and achieve the 95-95-95 targets toward Ending AIDS 2030.

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Availability

Detail Information

Series Title

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Call Number

T1884322025

Publisher

Indralaya : Prodi Kesehatan Masyarakat (S2), Fakultas Kesehatan Masyarakat Universitas Sriwijaya., 2025

Collation

xv, 237 hlm.; ilus.; tab.; 29 cm.

Language

Indonesia

ISBN/ISSN

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Classification

614.599 07

Content Type

Text

Media Type

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Carrier Type

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Edition

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Subject(s)

Prodi Kesehatan Masyarakat (S2)
HIV (Penyakit) – Sumatera Selatan

Specific Detail Info

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Statement of Responsibility

TUTI

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