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UJI AKTIVITAS PERBAIKAN FUNGSI GINJAL EKSTRAK ETANOL KULIT BATANG SUKUN (Artocarpus altilis) PADA TIKUS WISTAR YANG DIINDUKSI NEFROTOKSIK

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The stem bark of breadfruit is known to contain bioactive compounds in the from flavonoids, which have antioxidant and anti inflammatory activities. These compounds have the potential to help reduce oxidative stress and inflammation in kidneys that experience demage due to exposure to nephrotoxic agents. This study aims to evaluate the activity of the ethanol extract of breadfruit stem bark (EEKBS) on the improvement of kidney function in nephrotoxicity induced rats using gentamicin and piroxicam. The assessment of kidney function improvement was conducted through biochemical parameters including urine volume, urine pH, serum creatinine levels, serum urea levels, urine protein levels, urinary creatinine clerance, and kidney histopathological analysis. The test animals were devided into six groups, namely the normal group (NaCMC 0,5%), the negative control group (gentamicin 100 mg/kgBW and piroxicam 3,6 mg/kgBW), the positive control (ketosteril 55 mg/kgBW), and the trearment groups with ethanol extract of breadfruit stem bark at doses of 100, 200, and 400 mg/kgBW. Nephrotoxic agent induction was carried out for 7 days, followed by administration of ketosteril and the extract for 21 days. Urine parameters were observed after induction and after treatment, while biochemical and histopathological analyses were conducted at the end of the study. The result showed that administration of EEKBS at doses 100, 200, 400 mg/kgBW was able to improve kidney function significantly (p>0,05) by reducing creatinine, urea, urin protein levels, increasing creatinine clearance and urine volume compared with the negative control. The dose of 400 mg/kgBW provided a more effective kidney function improvement activity compared with the positive control, as indicated by better biochemical parameters and histopathological findings with milder tissue demage. Keywords: Artocarpus altilis, flavonoids, gentamicin, kidney function, nephrotoxicity

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Detail Information

Series Title

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Call Number

T1929432026

Publisher

Indralaya : Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2026

Collation

xviii, 133 hlm.; ilus.; tab.; 29 cm.

Language

Indonesia

ISBN/ISSN

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Classification

615.321 07

Content Type

Text

Media Type

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Carrier Type

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Edition

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Subject(s)

Prodi Ilmu Farmasi
Ekstrak Etanol Kulit Batang Sukun

Specific Detail Info

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Statement of Responsibility

MI

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