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PERBANDINGAN EFEK FENTANYL DAN SUFENTANIL TERHADAP RESPONS HEMODINAMIK SAAT LARINGOSKOPI INTUBASI PASIEN HIPERTENSI

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Introduction: Laryngoscopy and endotracheal intubation may provoke sympathetic activation, resulting in increased blood pressure and heart rate, particularly in hypertensive patients. Opioids such as fentanyl and sufentanil are commonly used to attenuate this hemodynamic response. However, comparative evidence regarding their effects in hypertensive patients remains limited. Methods: This double-blind randomized controlled trial included 72 hypertensive patients classified as ASA II. Participants were randomly assigned to receive either fentanyl 3 µg/kg or sufentanil 0.3 µg/kg (n = 36 per group). Systolic blood pressure, diastolic blood pressure, mean arterial pressure (MAP), and heart rate were measured at six time points, from pre-induction to six minutes after intubation. Statistical analyses were performed using independent t-tests, paired t-tests, and a General Linear Model (GLM) with repeated measures. Results: A total of 72 hypertensive ASA II patients were equally allocated to fentanyl and sufentanil groups. Baseline characteristics and hemodynamic parameters were comparable, including systolic blood pressure (153.08 ± 10.88 vs 154.36 ± 11.23 mmHg; p = 0.626) and mean arterial pressure (107.67 ± 3.89 vs 108.01 ± 5.93 mmHg; p = 0.779). All hemodynamic variables changed significantly over time (GLM repeated measures, p < 0.001). Following induction and during intubation, the sufentanil group demonstrated lower systolic blood pressure (T1: 109.97 ± 9.01 vs 131.81 ± 6.90 mmHg; p < 0.001), mean arterial pressure (85.82 ± 6.33 vs 93.82 ± 4.07 mmHg; p < 0.001), and heart rate (83.78 ± 8.45 vs 88.83 ± 4.06 beats/min; p = 0.002) compared with fentanyl. No clinically significant adverse effects were observed. Conclusion: Fentanyl and sufentanil effectively attenuate hemodynamic responses to laryngoscopy and intubation in hypertensive patients. However, sufentanil provides more stable and superior hemodynamic control during induction and early post-intubation compared with fentanyl. Keywords: Fentanyl, Sufentanil, Hemodynamic Response, Laryngoscopy, Intubation, Hypertesion

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Detail Information

Series Title

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Call Number

T1928302026

Publisher

: Prodi Pendidikan Dokter Spesialis, Fakultas Kedokteran Universitas Sriwijaya., 2026

Collation

xvi, 187 hlm.; ilus.; tab.; 29 cm.

Language

Indonesia

ISBN/ISSN

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Classification

617.965 07

Content Type

Text

Media Type

-

Carrier Type

-

Edition

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Subject(s)

Prodi Pendidikan Dokter Spesialis
Teknik Anestesi--Intubasi

Specific Detail Info

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MI

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