Skripsi

UJI AKTIVITAS ANTIDIABETES DAN HISTOPATOLOGI PANKREAS EKSTRAK ETANOL DAUN KECIPIR (Psophocarpus tetragonolobus (L.) DC) PADA TIKUS PUTIH WISTAR JANTAN KONDISI HIPERGLIKEMIK

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Winged bean (Psophocarpus tetragonolobus (L.) DC) is known to contain various bioactive compounds with potential antidiabetic properties. This study aimed to determine the characteristics and antidiabetic activity of the ethanolic extract of winged bean leaves, as well as to evaluate pancreatic histopathological changes in hyperglycemic male Wistar rats. Type 2 diabetes mellitus was induced by administering a high-fat and fructose diet consisting of fructose at a dose of 1800 mg/kgBW and a high-fat diet containing 15% lard and 5% duck egg yolk for 30 days. The animals were divided into six groups: normal group, negative control (0,5% Na CMC), positive control (metformin 45 mg/200 gBW), and three treatment groups receiving the ethanolic extract of winged bean leaves at doses of 100, 200, and 400 mg/kgBW for 15 days. Extract characterization results showed a moisture content of 5,33%, total ash content of 8,33%, water-soluble extractive value of 25%, and ethanol-soluble extractive value of 78,33%. The results demonstrated that administration of the ethanolic extract of winged bean leaves significantly reduced blood glucose levels compared to the negative control. The AUC₀₋₁₅ values and percentages of blood glucose reduction at doses of 100, 200, and 400 mg/kgBW were 2008,75 and 48,95%; 1948,06 and 54,92%; and 1796,88 and 69,79%, respectively, with the best effect observed at a dose of 400 mg/kgBW weight, which was comparable to the positive control. Based on the dose–response relationship between blood glucose reduction percentage and extract dose, the ED₅₀ value of the ethanolic extract of winged bean leaves was determined to be 120,869 mg/kgBW. Pancreatic histopathological examination at a dose of 400 mg/kgBW showed improvement, indicated by reduced degeneration, necrosis, and inflammatory cell infiltration in the islets of Langerhans.

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Detail Information

Series Title

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Call Number

T1936512026

Publisher

Indralaya : Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2026

Collation

xviii, 88 hlm.; ilus.; tab.; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

615.321 07

Content Type

Text

Media Type

unmediated

Carrier Type

-

Edition

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Subject(s)

Prodi Ilmu Farmasi
Daun Kecipir

Specific Detail Info

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Statement of Responsibility

KA

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