Skripsi

FORMULASI NANOEMULGEL EKSTRAK ETANOL DAUN SUKUN (Artocarpus altilis) DENGAN VARIASI GELLING AGENT DAN UJI AKTIVITASNYA PADA PENYEMBUHAN LUKA BAKAR

---

Burns are complex skin injuries that require immediate treatment to prevent infection and accelerate tissue regeneration. The breadfruit plant (Artocarpus altilis) contains flavonoid compounds, such as quercetin, which possess anti-inflammatory and antioxidant activities to support wound healing. However, the utilization of natural extracts is often hindered by low solubility and poor stability. This study aims to formulate a nanoemulgel of breadfruit leaf ethanolic extract with variations in the types and concentrations of gelling agents and to evaluate its in vivo burn healing effectiveness. The nanoemulgel was formulated using Carbopol 940® (0.4% and 0.8%) and Na-CMC (2% and 3%) as gelling agents. The evaluation of the nanoemulgel—including organoleptic properties, pH, viscosity, adhesion, spreadability, drug content, and stability through cycling and short-term tests—showed that the optimal formulation was Formula 3, which utilized 2% Na-CMC. The average results for pH, viscosity, adhesion, spreadability, and drug content were 6.20±0.10; 4305.95±26.75 cP; 121.33±1.53 s; 5.73±0.25 cm; and 96.90±1.23%, respectively. In vitro penetration testing conducted on the breadfruit leaf extract, nanoemulsion, and the optimized nanoemulgel yielded release percentages of 42.03, 89.09, and 85.08%, respectively. Compartmental model analysis indicated that all three dosage forms followed a three-compartment model, suggesting the presence of a lag time, defined as the interval between drug administration and its initial detection in systemic circulation (p < 0.05). The in vivo test results showed that the Formula 3 nanoemulgel group had a recovery rate of 89.88±0.56%, closely approaching the positive control group's (Bioplacenton®) recovery rate of 93.16±0.15%. Histopathological analysis revealed that the Formula 3 nanoemulgel produced a healing profile comparable to the positive control group, characterized by the formation of organized collagen tissue and the absence of erosion or active inflammation. Keyword(s): breadfruit leaves, burn wounds, flavonoids, nanoemulgel, nanoemulsion

---

Availability

Detail Information

Series Title

-

Call Number

T1938752026

Publisher

Indralaya : Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2026

Collation

xiv, 178 hlm.; ilus.; tab.; 29 cm.

Language

Indonesia

ISBN/ISSN

-

Classification

615.321 07

Content Type

Text

Media Type

-

Carrier Type

-

Edition

-

Subject(s)

Prodi Ilmu Farmasi
Formulasi farmasi

Specific Detail Info

-

Statement of Responsibility

TUTI

Other version/related

File Attachment

Comments

---

You must be logged in to post a comment