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NETWORK PHARMACOLOGY DAN MOLECULAR DOCKING EKSTRAK DAUN BIDARA (Ziziphus mauritiana) TERHADAP AKTIVITAS ANTINEUROINFLAMASI PADA TERAPI PENYAKIT ALZHEIMER

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Alzheimer’s disease is a progressive neurodegenerative disorder and the leading cause of dementia worldwide, affecting over 55 million people in 2020. Pathologically, Alzheimer’s is characterized by the accumulation of β-amyloid plaques, hyperphosphorylation of tau protein, and chronic neuroinflammation triggered by microglial activation and the release of pro-inflammatory cytokines such as TNF-α and IL-1β. This neuroinflammatory responsse contributes to oxidative stress thereby accelerating disease progression. Current therapeutic options primarily alleviate symptoms without halting neuronal degeneration and often face limitations such as poor BBB penetration and potential adverse effects. Ziziphus mauritiana has emerged as a promising natural source of bioactive compounds, including flavonoids, fatty acids, alkaloids, and saponins, which are known for their antioxidant and anti-inflammatory properties. This study aims to evaluate the potential antineuroinflammatory activity of bioactive compounds from Ziziphus mauritiana against Alzheimer’s disease using an in silico approach. Compound identification was performed using LC-HRMS, while target prediction was conducted through SwissTargetPrediction and GeneCards. Network pharmacology analyses were carried out using STRING, STITCH, and Cytoscape. Molecular docking using AutoDock Vina. The results identified three key targets APP, IL-1β, and TNF along with seven potential active compounds. The docking results indicated that quercetin–APP (−4.540 kcal/mol), quercetin–IL-1β (−6.746 kcal/mol), and myricetin–TNF (−6.180 kcal/mol) exhibited higher binding affinity and interaction stability than dapansutrile. These findings suggest that Ziziphus mauritiana possesses promising antineuroinflammatory potential and may serve as a valuable candidate for Alzheimer’s disease therapy. Keyword(s): Alzheimer’s disease, in silico, molecular docking, neuroinflammation, Ziziphus mauritiana

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Detail Information

Series Title

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Call Number

T1931412026

Publisher

Indralaya : Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2026

Collation

xxi, 161 hlm.; ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

615.190 028 507

Content Type

Text

Media Type

unmediated

Carrier Type

-

Edition

-

Subject(s)

Prodi Ilmu Farmasi
Alzheimer

Specific Detail Info

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Statement of Responsibility

KA

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