Skripsi

KORELASI KADAR BRAIN DERIVED NEUROTROPHIC FACTOR DAN FUNGSI KOGNITIF PADA PASIEN USIA LANJUT DI INSTALASI RAWAT JALAN GERIATRI RSMH PALEMBANG

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ABSTRACT THE CORRELATION OF BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) AND COGNITIVE FUNCTION IN ELDERLY PATIENTS AT THE GERIATRIC OUTPATIENT CLINIC OF RSMH PALEMBANG Devin Fidela, Yuniza, Nur Riviati, Iche A. Liberty Department of Internal Medicine, Faculty of Medicine, Sriwijaya University Dr. Mohammad Hoesin Hospital Palembang Background: Cognitive impairment represents a major public health challenge in ageing populations and is a key determinant of disability and reduced quality of life. Brain-Derived Neurotrophic Factor (BDNF) plays a pivotal role in synaptic plasticity, learning, and memory. Reduced BDNF levels have been implicated in neurodegenerative processes; however, clinical evidence from geriatric populations in low- and middle-income countries remains limited. Methods: This observational analytic study employed a cross-sectional design involving geriatric outpatients aged ≥60 years recruited consecutively at a tertiary referral hospital in Indonesia. Cognitive function was assessed using the Indonesian version of the Montreal Cognitive Assessment (MoCA-INA). Serum BDNF concentrations were measured using enzyme-linked immunosorbent assay (ELISA). Statistical analyses included Spearman’s correlation, receiver operating characteristic (ROC) curve analysis, and multivariable linear regression to identify independent determinants of cognitive performance. Results: A total of 70 participants were included, the majority of whom exhibited cognitive impairment. Serum BDNF levels demonstrated a significant positive correlation with MoCA-INA scores (r = 0.642; p < 0.001). ROC analysis revealed good discriminative accuracy of serum BDNF for cognitive impairment (AUC = 0.874), with an optimal cut-off value of ≤2005.42 pg/mL. In multivariable analysis, serum BDNF levels and nutritional status remained independently associated with cognitive performance, accounting for approximately 46% of the variance. Conclusion: Serum BDNF levels are strongly associated with cognitive function in older adults. These findings support the potential role of BDNF as a biological marker for early identification of cognitive impairment in geriatric populations. Keywords: brain-derived neurotrophic factor, cognitive function, ageing, MoCA, biomarker

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Detail Information

Series Title

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Call Number

T1938092026

Publisher

Indralaya : Prodi Pendidikan Dokter Spesialis, Fakultas Kedokteran Universitas Sriwijaya., 2026

Collation

xi, 29 hlm.; ilus.; tab.; 29 cm.

Language

Indonesia

ISBN/ISSN

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Classification

616.830 7

Content Type

Text

Media Type

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Carrier Type

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Edition

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Subject(s)

Fungsi Kognitif
Prodi Pendidikan Dokter Spesialis

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Statement of Responsibility

TUTI

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