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PERBANDINGAN KOMBINASI INJEKSI PERINEURAL DAN ORAL MECOBALAMIN DENGAN TERAPI ORAL MECOBALAMIN TERHADAP PERBAIKAN GEJALA SENSORIK PADA PASIEN CARPAL TUNNEL SYNDROME

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Background: Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy, predominantly presenting with sensory symptoms such as numbness and tingling. Conservative therapy with oral mecobalamin is widely used; however, the onset of improvement is often slow. Perineural injection of mecobalamin may provide a faster local effect, but clinical evidence remains limited. This study aimed to evaluate the effectiveness of combined perineural injection and oral mecobalamin compared with oral mecobalamin alone on sensory symptom improvement in CTS patients. Methods: This was a comparative interventional study conducted on patients with mild to moderate CTS at Dr. Mohammad Hoesin General Hospital, Palembang. Subjects were divided into two groups: a combination therapy group (perineural injection plus oral mecobalamin) and an oral mecobalamin group. Sensory symptoms were assessed using the visual analog scale (VAS) at baseline, week 2, and week 4. Results: A total of 30 CTS patients were included in this study. There were no significant differences in baseline demographic and clinical characteristics between groups. Mixed ANOVA analysis demonstrated a significant time effect (p < 0.001) and a significant time–group interaction, indicating a faster pattern of sensory symptom improvement (VAS score reduction) in the combination group. Multivariate analysis showed that combination therapy, sex, and occupation were independently associated with sensory symptom improvement, with occupation being the most dominant factor. Conclusion: The combination of perineural injection and oral mecobalamin is more effective in accelerating and enhancing sensory symptom improvement compared with oral mecobalamin therapy alone in patients with mild to moderate CTS. Keywords: carpal tunnel syndrome, mecobalamin, perineural injection, sensory symptoms, VAS

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Detail Information

Series Title

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Call Number

T1930872026

Publisher

Indralaya : Prodi Pendidikan Dokter Spesialis, Fakultas Kedokteran Universitas Sriwijaya., 2026

Collation

xvi, 138 hlm.; ilus.; tab.; 29 cm.

Language

Indonesia

ISBN/ISSN

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Classification

616.830 7

Content Type

Text

Media Type

-

Carrier Type

-

Edition

-

Subject(s)

Penyakit sistem saraf
Prodi Pendidikan Dokter Spesialis

Specific Detail Info

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TUTI

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