Skripsi

HUBUNGAN ANTARA RASIO LDL/APO B DAN VASCULAR COGNITIVE IMPAIRMENT PADA PASIEN STROKE ISKEMIK DI POLIKLINIK MEMORI RSUP Dr. MOHAMMAD HOESIN PALEMBANG

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Background: Vascular Cognitive Impairment (VCI) represents a leading cause of post-stroke cognitive impairment in Asia, including Indonesia, with substantial implications for quality of life and economic burden. Current management strategies emphasize early detection through the identification of specific biomarkers as predictive factors. The LDL/ApoB ratio is considered a more accurate surrogate than conventional cholesterol measurements for estimating the atherogenic small dense LDL (sdLDL) fraction. This study aimed to investigate the association between the LDL/ApoB ratio and the occurrence of VCI in ischemic stroke patients. Methods: This study employed an analytical observational design with a comparative approach. The study population comprised 42 ischemic stroke patients (21 with VCI and 21 non-VCI) attending the Memory Outpatient Clinic of Dr. Mohammad Hoesin General Hospital, Palembang, from March 2025 to February 2026. Bivariate analysis was performed using the chi-square test for demographic and clinical characteristics, and either the independent samples t-test or Mann–Whitney U test for lipid profile comparisons. Multivariate logistic regression analysis was subsequently conducted to identify the variables most significantly associated with the occurrence of VCI. Results: No statistically significant differences were observed in demographic characteristics (age, sex, educational level) or lipid profiles (total cholesterol, LDL, HDL, ApoB) between the two groups. However, statistically significant differences were identified in the location of strategic infarct lesion (p = 0.004; POR 8.00), serum triglyceride levels (p = 0.001), and the LDL/ApoB ratio (p = 0.006). The mean LDL/ApoB ratio was significantly lower in the VCI group (1.21 ± 0.24) compared to the non-VCI group (1.47 ± 0.31). Multivariate analysis identified the LDL/ApoB ratio (OR 0.014; p = 0.009) and triglyceride levels (OR 1.021; p = 0.011) as the strongest independent predictors of VCI, with the combined model yielding an area under the curve (AUC) of 0.841. Conclusion: A low LDL/ApoB ratio and elevated triglyceride levels are the principal factors most strongly associated with the occurrence of VCI in ischemic stroke patients. Strategic infarct lesion location also demonstrates a significant contribution to post-stroke cognitive decline. The predictive model incorporating the LDL/ApoB ratio and triglyceride levels achieved a sensitivity of approximately 90% at a probability cut-off of >0.31, supporting its potential utility as a practical screening tool for post-stroke cognitive impairment risk in clinical settings.

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Detail Information

Series Title

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Call Number

T1938052026

Publisher

Indralaya : Prodi Pendidikan Dokter Spesialis, Fakultas Kedokteran Universitas Sriwijaya., 2026

Collation

xvii, 131 hlm.; ilus.; tab.; 29 cm.

Language

Indonesia

ISBN/ISSN

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Classification

616.810 7

Content Type

Text

Media Type

-

Carrier Type

-

Edition

-

Subject(s)

stroke iskemik
Prodi Pendidikan Dokter Spesialis

Specific Detail Info

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Statement of Responsibility

TUTI

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