Skripsi

FORMULASI DAN UJI AKTIVITAS ANTIHIPERLIPIDEMIA FITOSOM EKSTRAK KULIT BAWANG MERAH (Allium cepa L.) SECARA IN VIVO

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Red onion peels (Allium cepa L.) contain quercetin flavonoid compounds that serve antihyperlipidemic activity. This study aimed to formulate phytosome preparations of shallot peel extract and evaluate their characteristics as well as their antihyperlipidemic activity in vivo. The phytosomes were prepared using variations of extract and phosphatidylcholine ratios by the thin-layer hydration method. A total of 30 rats were used and induced with hyperlipidemia for 30 days using a high-fat diet and propylthiouracil, followed by treatment for 14 days. Lipid levels were measured using the enzymatic colorimetric GPO-PAP method for triglycerides, the CHOD-PAP method for total cholesterol, the precipitation method for HDL, and an indirect method for LDL. The results showed that the best phytosome formula was F2 (1:2), which had the highest encapsulation efficiency of 88,10%, with physical characteristics including an average particle size of 382.67 ± 0.153 nm, a PDI of 0.434 ± 0.002, and a zeta potential of -17.87 ± 0.020 mV. The stability test showed a decrease in %EE to 83.51% with a reduction of 5.21%, and the lowest pH decrease of 0.59%, indicating that the best phytosome formulation was still able to maintain its stability. The antihyperlipidemic test of shallot peel extract phytosomes showed reductions in total cholesterol, triglycerides, and LDL levels by 52.95%, 42.53%, and 70.52%, respectively, and an increase in HDL levels by 71.81%. The effectiveness of the 1:2 phytosome formula was significantly better than that of shallot peel extract (p < 0.05), as supported by its greater percentage reduction in lipid levels. Macroscopic observation of the liver showed improved liver condition compared with the negative control. These findings indicate that shallot peel extract phytosomes possess antihyperlipidemic activity. Keyword(s): antihyperlipidemia, phosphatidylcholine, phytosome, red onion peel, propylthiouracil

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Detail Information

Series Title

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Call Number

T2005572026

Publisher

Indralaya : Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2026

Collation

xix, 168 hlm.; ilus.; tab.; 29 cm.

Language

Indonesia

ISBN/ISSN

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Classification

615.321 07

Content Type

Text

Media Type

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Carrier Type

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Edition

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Subject(s)

Prodi Ilmu Farmasi
Ekstrak Kulit Bawang Merah

Specific Detail Info

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Statement of Responsibility

MI

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