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UJI ANTIDIABETES FRAKSI ETANOL DAUN PALIASA (Kleinhovia hospita Linn.) PADA TIKUS JANTAN WISTAR YANG TERINDUKSI DIET TINGGI LEMAK-FRUKTOSA DAN STREPTOZOTOCIN

Type 2 diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia resulting from insulin resistance and pancreatic β-cell dysfunction. Limitations of conventional therapies, which may cause adverse effects, have encouraged the development of antidiabetic agents derived from natural products. Paliasa leaves (Kleinhovia hospita Linn.) are known to contain bioactive compounds, particularly flavonoids, which exhibit potential antidiabetic properties. This study aimed to evaluate the antidiabetic activity of the ethanol fraction of paliasa leaves in male Wistar rats induced with a high-fat and fructose diet (HFFD) and streptozotocin (STZ). This study was an experimental research employing a pretest–posttest control group design. The experimental animals were divided into six groups: normal group, negative control group, positive control group (metformin), and three treatment groups receiving the ethanol fraction of paliasa leaves at doses of 92.5, 185, and 370 mg/kg body weight. The observed parameters included fasting blood glucose levels, HbA1c levels, area under the curve (AUC) values, percentage reduction in blood glucose levels, determination of the effective dose (ED₅₀), and pancreatic histopathological features. The results showed that the ethanol fraction of paliasa leaves significantly reduced fasting blood glucose levels compared to the negative control group (p < 0.05). A dose-dependent reduction in AUC values was observed, with the dose of 370 mg/kg body weight demonstrating the best antidiabetic efficacy. Histopathological examination of the pancreas revealed improved islet of Langerhans structure and a reduced degree of β-cell damage in the treatment groups. Based on these findings, it can be concluded that the ethanol fraction of paliasa leaves exhibits antidiabetic activity, with a dose of 370 mg/kg body weight as the most effective dose, and has potential to be developed as a natural antidiabetic agent. Keywords: antidiabetic, type 2 diabetes mellitus, ethanol fraction, Kleinhovia hospita Linn.

Availability
#
Central Library (Reference) T1935552026
T193555
Available but not for loan - Not for Loan
Detail Information
Series Title
-
Call Number
T1935552026
Publisher
Indralaya : Prodi Ekonomi Akuntansi, Fakultas Ekonomi Universitas Sriwijaya.,
Collation
xi, 83 hlm.; ilus.; 29 cm
Language
Indonesia
ISBN/ISSN
-
Classification
615.321 07
Content Type
Text
Media Type
unmediated
Carrier Type
-
Edition
-
Subject(s)
Diabetes Melitus Tipe 2
Prodi Ekonomi Akuntansi
Specific Detail Info
-
Statement of Responsibility
Other version/related
TitleEditionLanguage
AKTIVITAS HIPOGLIKEMIK FRAKSI ETIL ASETAT DAUN PALIASA (KLEINHOVIA HOSPITA LINN.) TERHADAP TIKUS JANTAN WISTAR TERINDUKSI DIET HIPERLIPIDEMIK DAN STREPTOZOTOCIN-id
RASIONALITAS PENGGUNAAN OBAT DIABETES MELITUS GOLONGAN BIGUANID (METFORMIN) PADA PASIEN DIABETES MELITUS TIPE 2 DI RSMH PALEMBANG PERIODE 1 JULI 2019-31 JULI 2020id
HUBUNGAN LAMA MENDERITA DIABETES MELITUS TIPE 2 DENGAN JENIS RETINOPATI DIABETIK DI RSUP DR.MOHAMMAD HOESIN PALEMBANG TAHUN 2019-2020id
FAKTOR-FAKTOR YANG MEMPENGARUHI TERKENDALINYA KADAR HbA1c PENDERITA DIABETES MELITUS TIPE 2 PADA PESERTA PROGRAM PENGELOLAAN PENYAKIT KRONIS (PROLANIS) DI PUSKESMAS SEKIP TAHUN 2021id
EFEK PEMBERIAN STREPTOZOTOCIN TERHADAP KOLESTEROL TOTAL PADA TIKUS MODEL DIABETES MELITUSid
AKTIVITAS HIPOGLIKEMIK FRAKSI ETIL ASETAT DAUN PALIASA (KLEINHOVIA HOSPITA LINN.) TERHADAP TIKUS JANTAN WISTAR TERINDUKSI DIET HIPERLIPIDEMIK DAN STREPTOZOTOCIN-id
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