Skripsi

AKTIVITAS HIPOGLIKEMIK FRAKSI ETIL ASETAT DAUN PALIASA (KLEINHOVIA HOSPITA LINN.) TERHADAP TIKUS JANTAN WISTAR TERINDUKSI DIET HIPERLIPIDEMIK DAN STREPTOZOTOCIN

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Diabetes mellitus is a chronic metabolic disease characterized by persistent hy-perglycemia resulting from impaired secretion and/or action of insulin. The in-creasing need for long-term therapy has encouraged the development of antidia-betic agents derived from natural products that are safer and more affordable. Kleinhovia hospita Linn. leaves have been empirically used to reduce blood glu-cose levels and are known to contain bioactive compounds, particularly flavo-noids and phenolics. This study aimed to evaluate the hypoglycemic activity of the ethyl acetate fraction of Kleinhovia hospita leaves in a type 2 diabetes melli-tus model. Male Wistar rats were divided into six groups: normal, negative con-trol, positive control (metformin), and treatment groups receiving the ethyl ace-tate fraction of Kleinhovia hospita leaves at doses of 100, 200, and 400 mg/kg body weight. Diabetes was induced by administering a high-fat–fructose diet for 15 days, followed by an intraperitoneal injection of streptozotocin at a dose of 35 mg/kg body weight on day 12, and subsequently treated for 15 days. The evaluat-ed parameters included the percentage reduction in blood glucose levels (%PKGD), glycated hemoglobin (HbA1c) levels, pancreatic histopathological features, and determination of the effective dose 50% (ED₅₀). The results showed that all doses of the ethyl acetate fraction of Kleinhovia hospita leaves produced %PKGD values that were not significantly different (p > 0.05) from those of the metformin-treated group. HbA1c levels below 4% in the treated groups indicated an improvement in long-term glycemic control, accompanied by improved pan-creatic histological structure and reduced β-cell damage, particularly at the dose of 400 mg/kg body weight, which approached the normal group. The ethyl ace-tate fraction of Kleinhovia hospita leaves exhibited hypoglycemic activity with an ED₅₀ value of 300.731 mg/kg body weight, indicating its potential for further development as an antidiabetic agent. Keyword(s): diabetes mellitus, HbA1c, hypoglycemic, Kleinhovia hospita, pan- creatic histopathology

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Detail Information

Series Title

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Call Number

T1935032026

Publisher

Indralaya : Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2026

Collation

xxii, 144 hlm.; ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

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Classification

615.321 07

Content Type

Text

Media Type

unmediated

Carrier Type

-

Edition

-

Subject(s)

Prodi Ilmu Farmasi
Induksi Diet Hiperlipidemik -- Streptozotocin

Specific Detail Info

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Statement of Responsibility

KA

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