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PERBANDINGAN ANTARA EARLY CORD CLAMPING DAN DELAYED CORD CLAMPING TERHADAP LUARAN KEHAMILAN DI RS MOHAMMAD HOESIN PALEMBANG
Background: Postpartum hemorrhage (PPH) remains a leading cause of maternal morbidity and mortality globally, particularly in developing countries. As part of strategies aimed at preventing and managing PPH, the timing of umbilical cord clamping is an important component of active management of the third stage of labor and may influence both maternal and neonatal outcomes. Early cord clamping and delayed cord clamping are the two principal approaches currently used in obstetric practice. Although delayed cord clamping during cesarean delivery has demonstrated several advantages for both mothers and neonates, further evaluation is needed to establish its clinical effectiveness and safety in comparison with early cord clamping. Objective: To compare neonatal and maternal outcomes between early cord clamping and delayed cord clamping in elective cesarean section at Mohammad Hoesin Hospital Palembang. Methods: This randomized controlled trial included 96 subjects, allocated into 48 subjects in the ECC group and 48 subjects in the DCC group. Neonatal outcomes included hemoglobin, hematocrit, leukocyte count, platelet count at 12 hours after birth, and the 5-minute APGAR score. Maternal outcomes included hemoglobin, hematocrit, leukocyte count, and platelet count before and after the procedure, including their changes. Results: Maternal age was significantly higher in the ECC group than in the DCC group (32.94±6.71 vs 29.67±6.20 years; p=0.015), while other baseline characteristics were comparable. No statistically significant differences were found in neonatal outcomes, including hemoglobin (p=0.924), hematocrit (p=0.921), leukocyte count (p=0.910), platelet count (p=0.508), and 5-minute APGAR score (p=0.107). In maternal outcomes, the DCC group showed better results, as indicated by a smaller decrease in hemoglobin (ΔHb; p=0.016), higher postprocedural hematocrit (p=0.033), a smaller decline in hematocrit (ΔHt; p=0.026), and a more favorable platelet change (p=0.040). Conclusion: Early cord clamping (ECC) and delayed cord clamping (DCC) demonstrated comparable effects on neonatal clinical outcomes during the first 12 hours of life. However, DCC confers an additional benefit in enhancing maternal hematological stability.
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