Skripsi

EFEKTIVITAS EKSTRAK ETANOL DAUN SUNGKAI (Peronema canescens Jack.) SEBAGAI TERAPI PEPTIC ULCER PADA TIKUS PUTIH JANTAN GALUR WISTAR MODEL TUKAK LAMBUNG

---

Peptic ulcer disease is a gastrointestinal disorder characterized by damage to the gastric mucosa due to an imbalance between aggressive and protective factors. Conventional therapies such as proton pump inhibitors are effective but may cause adverse effects with long-term use, highlighting the need for safer alternative treatments. Sungkai leaves (Peronema canescens Jack.) are known to contain flavonoids and phenolic compounds with potential gastroprotective activity. This study aimed to evaluate the effectiveness of the ethanol extract of sungkai leaves as a therapy for peptic ulcer in male Wistar rats induced by ethanol. This study was an in vivo experimental study using 30 rats divided into six groups: normal, negative control, positive control (omeprazole 20 mg/kgBW), and treatment groups receiving ethanol extract of sungkai leaves at doses of 50, 100, and 200 mg/kgBW. The observed parameters included ulcer index, gastric pH, gastric volume and total acidity, mucin content, and histopathological features of gastric tissue. The results showed that administration of the ethanol extract of sungkai leaves significantly reduced ulcer index, gastric volume, and total acidity, while increasing gastric pH and mucin levels compared to the negative control (p < 0.05). Histopathological examination also demonstrated marked improvement of gastric mucosal structure, particularly at the dose of 200 mg/kgBW, which showed the most optimal therapeutic effect. In conclusion, the ethanol extract of sungkai leaves has potential as a peptic ulcer therapy through gastroprotective and therapeutic mechanisms reflected by improvements in physiological and structural gastric parameters. Keywords: ethanol extract, peptic ulcer, sungkai leaves, Wistar rats

---

Availability

Detail Information

Series Title

-

Call Number

T1965722026

Publisher

Indralaya : Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2026

Collation

xviii, 126 hlm.; ilus.; 29 cm

Language

Indonesia

ISBN/ISSN

-

Classification

615.321 07

Content Type

Text

Media Type

unmediated

Carrier Type

-

Edition

-

Subject(s)

Prodi Ilmu Farmasi
Sungkai (Peronema canescens)

Specific Detail Info

-

Statement of Responsibility

KA

Other version/related

File Attachment

Comments

---

You must be logged in to post a comment