Skripsi

NETWORK PHARMACOLOGY DAN MOLECULAR DOCKING DALAM MEMPREDIKSI AKTIVITAS DIABETES MELLITUS DARI EKSTRAK DAUN MATOA (Pometia Pinnata)

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Diabetes melitus (DM) is a chronic disease with a high prevalence in Indonesia, prompting the exploration of natural ingredients such as matoa (Pometia pinnata) leaves as a safer therapeutic alternative. This study aimed to identify bioactive compounds from matoa leaves using LC-HRMS, analyze their potential as antidiabetics through network pharmacology, and determine their interactions with target proteins through molecular docking. LC-HRMS analysis identified 403 metabolites, primarily composed of phenolics and flavonoids. A network pharmacology approach using STRING revealed 179 target proteins in 11 diabetes-related signaling pathways, with key proteins being AKT1, PPARG, PIK3CA, AMPK, SGLT2, DPP4, GLP1, alpha glucosidase, and insulin receptor. STITCH analysis revealed strong interactions between mevalonate and HMGCR (score 0.997), alpha aminobut and PPARG (0.847), and quercitrin and AKT1 (0.519). Molecular docking simulations confirmed quercitrin as the most potent compound with the best binding affinity to AKT1 (-8,148 kcal/mol), PPARG (-7,707 kcal/mol), PIK3CA (-9,638 kcal/mol), AMPKγ (-7,539 kcal/mol), SGLT2 (-8,422 kcal/mol), DPP4 (-8,806 kcal/mol), GLP1 (-7,643 kcal/mol), alpha glucosidase (-7,578 kcal/mol) and insulin receptor (-9,273 kcal/mol) through conventional hydrogen bonds and stable hydrophobic interactions. The results confirm that matoa leaf extract has potential as an antidiabetic agent through a multitarget mechanism, with quercitrin as a prime candidate for further development.

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Detail Information

Series Title

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Call Number

T1973632026

Publisher

Indralaya : Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya., 2026

Collation

xv, 128 hlm.; ilus.; tab.; 29 cm.

Language

Indonesia

ISBN/ISSN

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Classification

615.854 07

Content Type

Text

Media Type

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Carrier Type

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Edition

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Subject(s)

Prodi Ilmu Farmasi
Farmakologi dan terapi

Specific Detail Info

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Statement of Responsibility

TUTI

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