Image of NETWORK PHARMACOLOGY DAN MOLECULAR DOCKING DALAM MEMPREDIKSI AGEN TERAPI ULKUS DIABETIKUM BERBASIS EKSTRAK DAUN KELAPA SAWIT (Elaeis guineensis Jacq.)
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NETWORK PHARMACOLOGY DAN MOLECULAR DOCKING DALAM MEMPREDIKSI AGEN TERAPI ULKUS DIABETIKUM BERBASIS EKSTRAK DAUN KELAPA SAWIT (Elaeis guineensis Jacq.)

Diabetic ulcers are one of the chronic complications of diabetes mellitus, characterized by impaired wound healing due to prolonged inflammation, oxidative stress, and disrupted tissue regeneration. The complexity of their pathological mechanisms requires therapeutic strategies capable of targeting multiple molecular pathways at once, making the development of natural product–based therapies with multi-target properties a relevant approach in the management of diabetic ulcers. Oil palm leaves (Elaeis guineensis Jacq.) contain bioactive compounds with potential wound-healing activity and are therefore considered as candidate agents for diabetic ulcer therapy using a network pharmacology and molecular docking approach. Phytochemical compounds were identified using liquid chromatography–high resolution mass spectrometry (LC-HRMS), followed by network pharmacology analysis of the identified secondary metabolites. The results showed that the ethanol extract of oil palm leaves contains salidroside, isoquercetin, vicenin-2, isovitexin, orientin, kaempferol-3-O-rutinoside, and isoschaftoside. These compounds were predicted to interact with target proteins AKT1, CASP3, and HMGCR and to be involved in several signaling pathways related to diabetic wound healing, including the AGE-RAGE signaling pathway in diabetic complications, PI3K-AKT, HIF-1, MAPK, and AMPK signaling pathways. Molecular docking results showed that orientin had a lower binding energy toward AKT1 (−6.511 kkal/mol) than the reference compound quercetin (−5.842 kkal/mol). Isoschaftoside showed the strongest binding affinity toward CASP3 (−7.605 kkal/mol), which was better than quercetin (−6.447 kkal/mol) and the native CASP3 ligand (−6.701 kkal/mol). For the HMGCR target, orientin also showed a lower binding energy (−5.551 kkal/mol) compared to quercetin (−5.075 kkal/mol) and the native ligand simvastatin (−5.074 kkal/mol). These results suggest that the ethanol extract of oil palm leaves has potential as a natural multitarget therapy for diabetic ulcers based on in silico studies. Keyword(s): oil palm leaves, in silico, molecular docking, network pharmacology, diabetic ulcers

Availability
#
Central Library (Reference) T1966132026
T196613
Available but not for loan - Not for Loan
Detail Information
Series Title
-
Call Number
T1966132026
Publisher
Indralaya : Prodi Ilmu Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sriwijaya.,
Collation
xx, 201 hlm.; ilus.; 29 cm
Language
Indonesia
ISBN/ISSN
-
Classification
615.190 7
Content Type
Text
Media Type
unmediated
Carrier Type
-
Edition
-
Subject(s)
Prodi Ilmu Farmasi
Ulkus Diabetikum -- Pengobatan
Specific Detail Info
-
Statement of Responsibility
Other version/related
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