Image of POTENSI SENYAWA KATEKIN DALAM EKSTRAK GAMBIR (Uncaria gambir Roxb.) SEBAGAI INHIBITOR RESEPTOR HISTAMIN TIPE 1 (H1) UNTUK TERAPI INFLAMASI ORAL (Studi In Silico)
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POTENSI SENYAWA KATEKIN DALAM EKSTRAK GAMBIR (Uncaria gambir Roxb.) SEBAGAI INHIBITOR RESEPTOR HISTAMIN TIPE 1 (H1) UNTUK TERAPI INFLAMASI ORAL (Studi In Silico)

Background: Oral inflammation remains a common health problem in Indonesia. The use of nonsteroidal anti-inflammatory drugs (NSAIDs) as conventional therapy is effective; however, long-term use may cause various side effects. Therefore, safer natural-based alternative therapies are needed. Gambir (Uncaria gambir Roxb.) is known to contain catechin compounds with anti-inflammatory activity. Objective: This study aimed to analyze the potential of catechin against histamine type 1 receptors using an in silico approach. Materials and Methods: The materials used in this study were the 3D structure of the protein H1R and catechin ligand. The study was conducted in silico using Discovery Studio, AutoDock Tools 1.5.7., AutoDock Vina, and PyMOL software through protein and ligand preparation, virtual screening, method validation, and molecular docking stages. Results: Virtual screening demonstrated that catechin fulfilled the drug-likeness parameters and possessed favorable physicochemical characteristics. Method validation showed an RMSD value of < 2 Å, indicating that the docking method was valid. Docking results revealed that catechin exhibited good binding affinity toward the histamine type 1 receptor and formed hydrogen bond and hydrophobic interactions with key amino acid residues at the protein binding site. Conclusion: Catechin in gambir has the potential to be developed as a natural-based anti-inflammatory agent through inhibition of the histamine type 1 receptor.

Availability
#
Central Library (Reference) T2015772026
T201577
Available but not for loan - Not for Loan
Detail Information
Series Title
-
Call Number
T2015772026
Publisher
Indralaya : Prodi Kedokteran Gigi dan Mulut, Fakultas Kedokteran Universitas Sriwijaya.,
Collation
xvi, 89 hlm.; ilus.; tab.; 29 cm.
Language
Indonesia
ISBN/ISSN
-
Classification
615.321 07
Content Type
Text
Media Type
-
Carrier Type
-
Edition
-
Subject(s)
Prodi Kedokteran Gigi dan Mulut
Tanaman Obat--Ekstrak Gambir
Specific Detail Info
-
Statement of Responsibility
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No other version available

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