Background: Industrial noise exposure is a major occupational risk factor associated with noise-induced hearing loss (NIHL) and vestibular dysfunction. Continuous exposure to sound levels exceeding 85 dB is known to impair auditory and balance function. This study aimed to examine the correlation between noise intensity and duration of exposure with hearing impairment and balance impairment amo…
Background: Acute Kidney Injury (AKI), the most serious complications in critically ill patients admitted to the Intensive Care Unit (ICU). Under these conditions, the required renal replacement therapy modality that can be performed in the ICU is Continuous Renal Replacement Therapy (CRRT). However, the mortality rate remains high in patient with CRRT. This study aims to analyze the relationsh…
Background: An excessive inflammatory response and dysregulation of the immune system in severe sepsis may progress to septic shock and increase mortality. Vitamin D plays an important role in immune modulation. This study aimed to analyze the association between vitamin D levels and sepsis severity and to determine the cut-off point of vitamin D associated with the risk of septic shock in ICU …
Pendahuluan : Tekanan intraokular (TIO) memainkan peran penting dalam diagnosis dan manajemen beberapa penyakit mata, terutama yang terkait dengan peningkatan tekanan intraokular. Tingginya TIO dan Central Corneal Thickness (CCT) merupakan faktor risiko hilangnya penglihatan. Hingga saat ini Goldmann Applanation Tonometry (GAT) masih menjadi gold standard pengukuran TIO dan telah terdapat beber…
Background: Docetaxel is a chemotherapy drug used to inhibit cell cleavage in nasopharyngeal cancer. Canalicular and ductal stenosis is a common side effect of weekly docetaxel therapy, which often causes epiphora. This study aimed to analyze the correlation between the duration of docetaxel chemotherapy and lacrimal punctum stenosis in patients with nasopharyngeal cancer. Methods: This descrip…
Background: : Centella asiatica has long been used as a wound-healing agent due to its triterpenoid content, which possesses anti-inflammatory, antioxidant, and antifibrotic properties . During the wound healing process, TGF- β regulates re-epithelialization, inflammation, angiogenesis, and granulation tissue formation. Centella asiatica has been shown to decrease TGF-β 1, and contribute to t…
Background: Corneal incisions alter the curvature of the corneal surface, leading to surgically induced astigmatism (SIA). Temporal incisions are generally superior to superior incisions due to improved surgical access and lower SIA values. This study aims to analyze the survival of SIA values resulting from temporal corneal incisions in cataract patients undergoing phacoemulsification. Methods…
Introduction:Breast carcinoma is the most common breast malignancy among women in Indonesia,accounting for 30.8% of female cancer cases in 2020, with high prevalence at Dr. Mohammad Hoesin General Hospital (20.9% in 2019–2020). Serum calcium plays a crucial role in cellular regulation of cancer through homeostasis of PTH, vitamin D, and mechanisms such as PTHrP and local osteolysis, where hyp…
Background The prognosis of advanced-stage lung cancer remains poor despite ongoing therapeutic advances. Systemic inflammation and nutritional status are increasingly recognized as important prognostic determinants. The Advanced Lung Cancer Inflammation Index (ALI) is a prognostic parameter that evaluates the degree of systemic inflammation by combining body mass index (BMI), serum albumin lev…
Latar belakang: Coronary Artery Bypass Graft (CABG) adalah prosedur bedah jantung yang dapat memengaruhi hasil pascaoperasi, termasuk lama perawatan di ICU Kardiovaskular (CV ICU). Durasi CPB dan waktu klem aorta (AoX) yang berkepanjangan diduga berhubungan dengan peningkatan morbiditas serta perpanjangan masa perawatan pascaoperasi. Tujuan: Menentukan hubungan antara lama CPB dan waktu AoX den…
Background Hemorrhagic stroke is a neurological condition with high mortality, particularly in patients requiring mechanical ventilation due to decreased consciousness or respiratory failure. Initial neurological severity, comorbidities, and complications during hospitalization may influence patient outcomes. This study aimed to analyze factors associated with mortality in hemorrhagic stroke pa…
Background: Vascular Cognitive Impairment (VCI) represents a leading cause of post-stroke cognitive impairment in Asia, including Indonesia, with substantial implications for quality of life and economic burden. Current management strategies emphasize early detection through the identification of specific biomarkers as predictive factors. The LDL/ApoB ratio is considered a more accurate surroga…
Background: Stroke is a catastrophic disease with a significant economic burden, particularly for neurointervention procedures such as mechanical thrombectomy and coiling. A disparity exists between standard costs and actual billing charges for these procedures at Dr. Mohammad Hoesin Hospital Palembang. This study aimed to analyze the factors influencing hospitalization costs of stroke patients…
Background: Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy, predominantly presenting with sensory symptoms such as numbness and tingling. Conservative therapy with oral mecobalamin is widely used; however, the onset of improvement is often slow. Perineural injection of mecobalamin may provide a faster local effect, but clinical evidence remains limited. This study aimed t…
ABSTRACT THE CORRELATION OF BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) AND COGNITIVE FUNCTION IN ELDERLY PATIENTS AT THE GERIATRIC OUTPATIENT CLINIC OF RSMH PALEMBANG Devin Fidela, Yuniza, Nur Riviati, Iche A. Liberty Department of Internal Medicine, Faculty of Medicine, Sriwijaya University Dr. Mohammad Hoesin Hospital Palembang Background: Cognitive impairment represents a major public health c…
Background: Aging is often accompanied by cognitive decline, where Mild Cognitive Impairment (MCI) serves as a transitional phase at risk of developing into dementia. The pathophysiology of this condition is closely related to neurobiological mechanisms, including low levels of Brain-Derived Neurotrophic Factor (BDNF) and the high prevalence of Vitamin D insufficiency in the elderly population.…
Pendahuluan: Proses penuaan menyebabkan penurunan massa otot, kekuatan otot, dan performa fisik (sarkopenia), yang dipengaruhi oleh inflamasi kronik tingkat rendah dengan peningkatan kadar interleukin-6 (IL-6). Extra Virgin Olive Oil (EVOO) mengandung polifenol seperti hydroxytyrosol dan oleuropein yang bersifat antioksidan dan antiinflamasi, berpotensi memperbaiki fungsi otot pada lansia. Tuju…
Latar Belakang: Gangguan tidur pada remaja secara global cukup besar, sekitar 25-30%. Sementara itu gangguan pada proses tidur dapat menimbulkan masalah serius pada kesehatan fisik dan perilaku pada remaja. Tujuan: Mengidentifikasi faktor-faktor yang memengaruhi gangguan tidur pada remaja SMP di Palembang. Metode: Penelitian ini merupakan observasional analitik dengan desain potong lintang pada…
Penelitian ini dilakukan di Sungai Napalan, Desa Umpam, Kecamatan Lengkiti, Kabupaten Ogan Komering Ulu, Sumatera Selatan, yang bertujuan untuk menganalisis karakteristik mikrofosil foraminifera pada batugamping Formasi Baturaja bagian bawah, tengah, dan atas. Metode penelitian meliputi studi pendahuluan, observasi lapangan, analisis laboratorium, serta interpretasi data di studio. Dari 15 loka…
Latar Belakang: Vitamin D berperan penting sebagai pelindung dalam patogenesis sepsis dengan cara meredam inflamasi neutrofil dan menjaga fungsi limfosit. Rendahnya kadar vitamin D berkontribusi langsung pada buruknya profil hematologi (seperti tingginya RNL) dan peningkatan risiko gagal organ pada pasien sepsis. Penelitian ini bertujuan untuk mengetahui korelasi antara kadar vitamin D dengan r…
Introduction: Laryngoscopy and endotracheal intubation may provoke sympathetic activation, resulting in increased blood pressure and heart rate, particularly in hypertensive patients. Opioids such as fentanyl and sufentanil are commonly used to attenuate this hemodynamic response. However, comparative evidence regarding their effects in hypertensive patients remains limited. Methods: This doubl…
Pendahuluan: Pasien penyakit ginjal kronik (PGK) yang menjalani hemodialisis kronik memiliki risiko tinggi mengalami infeksi laten tuberkulosis (ILTB) akibat kondisi imunokompromais. Defisiensi vitamin D diketahui berperan dalam penurunan respons imun terhadap Mycobacterium tuberculosis. Namun, hubungan antara kadar vitamin D 25(OH) dengan kejadian ILTB pada populasi hemodialisis di Indonesia m…
Latar Belakang: Pasien penyakit ginjal kronik (PGK) yang menjalani hemodialisis memiliki risiko lebih tinggi mengalami infeksi laten tuberkulosis (ILTB) akibat disfungsi imun dan kondisi inflamasi kronis. High-sensitivity C-reactive protein (hsCRP) merupakan penanda inflamasi yang sering meningkat pada populasi ini, namun hubungannya dengan kejadian ILTB masih belum jelas terutama di Indonesia.…
Latar Belakang : Penuaan menyebabkan penurunan massa otot, kekuatan otot, dan performa fisik akibat proses inflamasi kronik derajat rendah yang ditandai peningkatan enzim COX-2 dan ROS. EVOO mengandung senyawa fenolik seperti oleocanthal dan hydroxytyrosol yang bersifat antioksidan dan antiinflamasi melalui inhibisi jalur NF-κB–COX-2, sehingga berpotensi menekan inflamasi dan mempertahankan …
Latar Belakang: Osteoartritis (OA) lutut merupakan salah satu penyakit sendi degeneratif yang ditandai dengan penipisan kartilago hialin dan inflamasi kronik. Vitamin D memiliki peran penting dalam metabolisme tulang, modulasi respon imun, dan aktivitas kondrosit. Penurunan kadar vitamin D serum diduga berhubungan dengan penurunan ketebalan kartilago hialin. OA menjadi masalah global karena dap…
This research aims to analyze the implementation of government economic policies regarding the South Sumatra Indonesian Young Entrepreneurs Association (HIPMI) in an effort to develop Micro, Small, and Medium Enterprises (MSMEs) in Palembang City. Utilizing the implementation model by Van Meter and Van Horn, this study evaluates six key dimensions: policy standards and objectives, resources, ch…
Background: Gastric adenocarcinoma remains a global health burden with high mortality, while effective targeted therapies are still limited. Claudin-18.2 is a transmembrane tight-junction protein selectively expressed in normal gastric mucosa and retained in gastric adenocarcinoma. Its role as a novel therapeutic target, including zolbetuximab, highlights the importance of investigating claudin…
ASSOCIATION BETWEEN RADIOLOGICAL EXAMINATION AND PIRANI SCORE IN PATIENTS WITH CONGENITAL TALIPES EQUINOVARUS (CTEV) WITH PONSETTI METHOD MANAGEMENT AT DR. MOHAMMAD HOESIN GENERAL HOSPITAL PALEMBANG Abstraìct Baìckground: Clinicaìl feaìtures of deformity haìve been claìssified by Piraìni, so thaìt its severity caìn be aìssessed aìt birth aìnd the progress of treaìtment caìn be mon…
Background: Vulvovaginal candidiasis (VVC) is a very common mucosal infection in the vagina and vulva, mostly caused by Candida albicans. Accurate diagnosis requires supportive examinations such as direct microscopic evaluation or fungal culture; however, in practice, these ancillary tests are often omitted in women presenting with vulvovaginal symptoms due to high patient burden and the need f…
Procedural pain is a common clinical issue in neonates, particularly during venipuncture. Inadequately managed pain can trigger physiological stress, hemodynamic instability, and may negatively affect long-term neurodevelopment. Non-pharmacological analgesic strategies such as oral dextrose have become a practical option due to their simplicity, safety, and ability to reduce reliance on pharmac…